Engineering the interface between lipid membranes and nanoporous gold

A study by quartz crystal microbalance with dissipation monitoring

Patricia Losada-Pérez, Ozge Polat, Atul N. Parikh, Erkin Seker, Frank Uwe Renner

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nanoporous gold (np-Au) is a nanostructured metal with many desirable attributes. Despite the growing number of applications of nanoporous materials, there are still open questions regarding their fabrication and subsequent surface functionalization. For example, the hydrophobic nature of gold surfaces makes the formation of planar supported lipid layers challenging. Here, the authors engineer the interface between np-Au and 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid layers using well-differentiated approaches based on vesicle adsorption and solvent exchange methods. The results reveal that the nanotopography of the np-Au surface plays a clear role in the vesicle adsorption process. Compared to vesicle adsorption, the solvent exchange method proves successful in the formation of planar supported lipid bilayers in both np-Au and planar Au surfaces, being less sensitive to the surface morphological features. The influence of nanostructured surfaces on lipid layer formation is determined by the driving mechanisms behind each process, i.e., the balance of adhesion and cohesion forces in vesicle adsorption and lyotropic lipid phase transitions in solvent exchange, respectively. A better understanding of such interactions will contribute to the development of a variety of applications, from electrochemical biosensors to drug screening and delivery systems, using nanoporous gold coated with stimuli-responsive lipid layers.

Original languageEnglish (US)
Article number011002
JournalBiointerphases
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

Quartz Crystal Microbalance Techniques
Quartz crystal microbalances
Membrane Lipids
quartz crystals
Gold
microbalances
lipids
dissipation
Lipids
Adsorption
engineering
gold
membranes
Monitoring
adsorption
Preclinical Drug Evaluations
Phase Transition
Lipid Bilayers
Biosensing Techniques
Drug Delivery Systems

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomaterials
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Engineering the interface between lipid membranes and nanoporous gold : A study by quartz crystal microbalance with dissipation monitoring. / Losada-Pérez, Patricia; Polat, Ozge; Parikh, Atul N.; Seker, Erkin; Renner, Frank Uwe.

In: Biointerphases, Vol. 13, No. 1, 011002, 01.02.2018.

Research output: Contribution to journalArticle

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