Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
Original language | English (US) |
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Pages (from-to) | 169-182 |
Number of pages | 14 |
Journal | Nature Reviews Neuroscience |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2011 |
ASJC Scopus subject areas
- Neuroscience(all)