Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-182 |
| Number of pages | 14 |
| Journal | Nature Reviews Neuroscience |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2011 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Engaging neuroscience to advance translational research in brain barrier biology. / Neuwelt, Edward A.; Bauer, Björn; Fahlke, Christoph; Fricker, Gert; Iadecola, Constantino; Janigro, Damir; Leybaert, Luc; Molnár, Zoltán; O'Donnell, Martha E; Povlishock, John T.; Saunders, Norman R.; Sharp, Frank R; Stanimirovic, Danica; Watts, Ryan J.; Drewes, Lester R.
In: Nature Reviews Neuroscience, Vol. 12, No. 3, 03.2011, p. 169-182.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Engaging neuroscience to advance translational research in brain barrier biology
AU - Neuwelt, Edward A.
AU - Bauer, Björn
AU - Fahlke, Christoph
AU - Fricker, Gert
AU - Iadecola, Constantino
AU - Janigro, Damir
AU - Leybaert, Luc
AU - Molnár, Zoltán
AU - O'Donnell, Martha E
AU - Povlishock, John T.
AU - Saunders, Norman R.
AU - Sharp, Frank R
AU - Stanimirovic, Danica
AU - Watts, Ryan J.
AU - Drewes, Lester R.
PY - 2011/3
Y1 - 2011/3
N2 - The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
AB - The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
UR - http://www.scopus.com/inward/record.url?scp=79951922143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951922143&partnerID=8YFLogxK
U2 - 10.1038/nrn2995
DO - 10.1038/nrn2995
M3 - Article
C2 - 21331083
AN - SCOPUS:79951922143
VL - 12
SP - 169
EP - 182
JO - Nature reviews. Neuroscience
JF - Nature reviews. Neuroscience
SN - 1471-003X
IS - 3
ER -