Endovascular treatment of dural sinus thrombosis with rheolytic thrombectomy and intra-arterial thrombolysis

Kira Chow, Y. Pierre Gobin, Jeffrey Saver, Chelsea Kidwell, Paul R Dong, Fernando Viñuela

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Background and Purpose - Cerebral venous thrombosis is a rare entity that can be difficult to manage. Intrasinus thrombolysis is an increasingly applied intervention, but this modality carries an increased risk of hemorrhage. We describe for the first time an option with a potentially lower incidence of intracranial bleeding, the combination of the AngioJet rheolytic thrombectomy catheter with intra-arterial thrombolysis, in 2 patients with extensive dural sinus thromboses, preexisting intracranial hemorrhage, and severe progressive neurological deficits despite heparin therapy. Methods - Four procedures were performed in 2 patients with thromboses in the superior sagittal and transverse sinuses (right in 1 patient and bilateral in 1 patient) and cortical veins. Rheolytic thrombectomy was performed in the sigmoid, transverse, straight, and superior sagittal sinuses; this technique revolves the use of the Bernoulli effect to create a vacuum that fragments and aspirates thrombus. For associated persistent cortical vein thromboses, low-dose intra-arterial thrombolysis was used. Results - Both patients had excellent angiographic results with sinus reopening after rheolytic thrombectomy and cortical vein reopening after intra-arterial thrombolysis. Follow-up CT showed no change in 1 patient and increased preexisting intracranial hemorrhage in the other. One patient had a negative hypercoagulable workup, and the other patient had probable anti-phospholipid antibody syndrome. At 6 months, both patients had excellent clinical outcome with no neurological deficits except mild short-term memory loss in 1 patient. Conclusions - The combination of rheolytic thrombectomy with intra- arterial thrombolysis is a treatment modality that allows accelerated recanalization of occluded dural sinuses and cerebral veins with lower doses of thrombolytic agents.

Original languageEnglish (US)
Pages (from-to)1420-1425
Number of pages6
JournalStroke
Volume31
Issue number6
StatePublished - 2000

Fingerprint

Intracranial Sinus Thrombosis
Thrombectomy
Superior Sagittal Sinus
Therapeutics
Veins
Thrombosis
Intracranial Hemorrhages
Transverse Sinuses
Hemorrhage
Cerebral Veins
Intracranial Thrombosis
Antiphospholipid Syndrome
Fibrinolytic Agents
Memory Disorders
Sigmoid Colon
Vacuum
Short-Term Memory
Venous Thrombosis
Heparin
Catheters

Keywords

  • Sinus thrombosis
  • Thrombectomy
  • Thrombolysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Chow, K., Gobin, Y. P., Saver, J., Kidwell, C., Dong, P. R., & Viñuela, F. (2000). Endovascular treatment of dural sinus thrombosis with rheolytic thrombectomy and intra-arterial thrombolysis. Stroke, 31(6), 1420-1425.

Endovascular treatment of dural sinus thrombosis with rheolytic thrombectomy and intra-arterial thrombolysis. / Chow, Kira; Gobin, Y. Pierre; Saver, Jeffrey; Kidwell, Chelsea; Dong, Paul R; Viñuela, Fernando.

In: Stroke, Vol. 31, No. 6, 2000, p. 1420-1425.

Research output: Contribution to journalArticle

Chow, K, Gobin, YP, Saver, J, Kidwell, C, Dong, PR & Viñuela, F 2000, 'Endovascular treatment of dural sinus thrombosis with rheolytic thrombectomy and intra-arterial thrombolysis', Stroke, vol. 31, no. 6, pp. 1420-1425.
Chow, Kira ; Gobin, Y. Pierre ; Saver, Jeffrey ; Kidwell, Chelsea ; Dong, Paul R ; Viñuela, Fernando. / Endovascular treatment of dural sinus thrombosis with rheolytic thrombectomy and intra-arterial thrombolysis. In: Stroke. 2000 ; Vol. 31, No. 6. pp. 1420-1425.
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AU - Viñuela, Fernando

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