Endotoxin and disease in food animals

James S Cullor, W. L. Smith

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


As infectious disease problems continue to plague food animal practice, an improved understanding of the causative agent and the pathophysiology of disease events will facilitate the development of prevention and treatment strategies. In food animals, gram-negative bacteria are responsible for clinical conditions that range from simple diarrhea to life-threatening meningoencephalitis. Current forms of treatment and management practices are only moderately successful. The ability to deliver cost-effective treatment for gram-negative bacterial disease and mediator-induced shock is vital to animal well-being and food safety issues. The information presented in this article is an overview of how the endotoxin molecule of gram-negative bacteria plays a role in initiating and amplifying disease processes in food animals. Because food animal practitioners are now responsible for guiding producers toward managing their herds in light of both animal health and public health, a renewed focus on gram-negative disease is especially pertinent.

Original languageEnglish (US)
JournalCompendium on Continuing Education for the Practicing Veterinarian
Issue numberSUPPL. 1
StatePublished - Jan 1996

ASJC Scopus subject areas

  • Education
  • veterinary(all)


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