Endotoxemia of metabolic syndrome: A pivotal mediator of meta-inflammation

Ishwarlal Jialal, Uthra Rajamani

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Endotoxemia, which is now emerging as a feature of metabolic syndrome, is believed to contribute to the chronic low-grade inflammatory status and insulin resistance of the syndrome. Lipopolysaccharides (LPS), or endotoxins, bind to LPS-binding protein and activate pattern recognition receptors, classically Toll-like receptor-4, mediating inflammation. Increased gut permeability and changes in composition and diversity of gut microbiome have been proposed as possible mechanisms to explain increased circulating endotoxins in metabolic syndrome. Endotoxins are also believed to be delivered into the circulation by chylomicrons. Weight loss and probiotic and prebiotic therapeutic strategies can reduce endotoxemia, inflammation, and insulin resistance in metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)454-456
Number of pages3
JournalMetabolic Syndrome and Related Disorders
Issue number9
StatePublished - 2014

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Medicine(all)


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