Endothelial cell growth factor enhances musculocutaneous flap survival through the process of neovascularization

Lee Li-Qun Pu, Syed Ahmed, J. Grant Thomson, Marjorie A. Reid, Jill A. Madsen, Richard J. Restifo

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The effect of an angiogenic growth factor-endothelial cell growth factor (ECGF)-was tested in the rat transverse rectus abdominis musculocutaneous (TRAM) flap model based on a single inferior vascular pedicle. The animals were divided into three groups (N = 8 per group) after flap elevation. In group A (control), each animal received both local and local intra-arterial injections of 1 ml saline. In group B (local), each received a 2-mg ECGF local injection and 1-ml saline local intra-arterial injection. In group C (local intra-arterial), each received a 1-ml saline local injection and a 2- mg ECGF local intra-arterial injection. All animals were evaluated on postoperative day 7. There was a significant increase in the percentage of the skin paddle survival area of the TRAM flap in both ECGF-treated groups when compared with the control group (group B vs. group A, p < 0.001; group C vs. group A, p < 0.001). This correlated with a significant increase in vascularity in both ECGF-treated groups compared with the control group (group B vs. group A, p = 0.007; group C vs. group A, p = 0.021). The results between groups B and C were not significant. ECGF, when administered via either local or local intra-arterial route, enhances musculocutaneous flap survival through the process of neovascularization.

Original languageEnglish (US)
Pages (from-to)306-312
Number of pages7
JournalAnnals of Plastic Surgery
Volume42
Issue number3
StatePublished - Mar 1999
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Pu, L. L-Q., Ahmed, S., Thomson, J. G., Reid, M. A., Madsen, J. A., & Restifo, R. J. (1999). Endothelial cell growth factor enhances musculocutaneous flap survival through the process of neovascularization. Annals of Plastic Surgery, 42(3), 306-312.