Endoscopic drainage aborts endotoxaemia in acute cholangitis

J. Y W Lau, S. M. Ip, S. C S Chung, Joseph Leung, T. K W Ling, M. Y. Yung, A. K C Li

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Forty patients with acute calculous cholangitis had successful endoscopic drainage. Bile from nasobiliary drains and venous blood was collected at 0, 12, 24, 36 and 48 h after endoscopy. Endotoxin levels were measured by the chromogenic Limulus Amoebocyte Lysate assay. There was a significant reduction in both bile and serum endotoxin levels after endoscopic drainage (P<0.001). Endotoxaemia occurred when bile endotoxin reached 103 EU/ml and rose exponentially beyond this threshold. Significant association was demonstrated between both bile and serum endotoxins to the clinical features of cholangitis (P < 0.05). No correlation was evident between serum endotoxin and the parameters of white cell count, serum bilirubin and alkaline phosphatase (r=0.53, 0.00 and 0.00 respectively). Endoscopic drainage is effective in lowering bile and serum endotoxin levels and clinical signs and symptoms reliably predict endotoxaemia.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalBritish Journal of Surgery
Volume83
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

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Cholangitis
Endotoxemia
Endotoxins
Drainage
Bile
Serum
Horseshoe Crabs
Bilirubin
Endoscopy
Signs and Symptoms
Alkaline Phosphatase
Cell Count

ASJC Scopus subject areas

  • Surgery

Cite this

Lau, J. Y. W., Ip, S. M., Chung, S. C. S., Leung, J., Ling, T. K. W., Yung, M. Y., & Li, A. K. C. (1996). Endoscopic drainage aborts endotoxaemia in acute cholangitis. British Journal of Surgery, 83(2), 181-184. https://doi.org/10.1002/bjs.1800830210

Endoscopic drainage aborts endotoxaemia in acute cholangitis. / Lau, J. Y W; Ip, S. M.; Chung, S. C S; Leung, Joseph; Ling, T. K W; Yung, M. Y.; Li, A. K C.

In: British Journal of Surgery, Vol. 83, No. 2, 1996, p. 181-184.

Research output: Contribution to journalArticle

Lau, JYW, Ip, SM, Chung, SCS, Leung, J, Ling, TKW, Yung, MY & Li, AKC 1996, 'Endoscopic drainage aborts endotoxaemia in acute cholangitis', British Journal of Surgery, vol. 83, no. 2, pp. 181-184. https://doi.org/10.1002/bjs.1800830210
Lau, J. Y W ; Ip, S. M. ; Chung, S. C S ; Leung, Joseph ; Ling, T. K W ; Yung, M. Y. ; Li, A. K C. / Endoscopic drainage aborts endotoxaemia in acute cholangitis. In: British Journal of Surgery. 1996 ; Vol. 83, No. 2. pp. 181-184.
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