Abstract
Forty patients with acute calculous cholangitis had successful endoscopic drainage. Bile from nasobiliary drains and venous blood was collected at 0, 12, 24, 36 and 48 h after endoscopy. Endotoxin levels were measured by the chromogenic Limulus Amoebocyte Lysate assay. There was a significant reduction in both bile and serum endotoxin levels after endoscopic drainage (P<0.001). Endotoxaemia occurred when bile endotoxin reached 103 EU/ml and rose exponentially beyond this threshold. Significant association was demonstrated between both bile and serum endotoxins to the clinical features of cholangitis (P < 0.05). No correlation was evident between serum endotoxin and the parameters of white cell count, serum bilirubin and alkaline phosphatase (r=0.53, 0.00 and 0.00 respectively). Endoscopic drainage is effective in lowering bile and serum endotoxin levels and clinical signs and symptoms reliably predict endotoxaemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-184 |
| Number of pages | 4 |
| Journal | British Journal of Surgery |
| Volume | 83 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
Endoscopic drainage aborts endotoxaemia in acute cholangitis. / Lau, J. Y W; Ip, S. M.; Chung, S. C S; Leung, Joseph; Ling, T. K W; Yung, M. Y.; Li, A. K C.
In: British Journal of Surgery, Vol. 83, No. 2, 1996, p. 181-184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endoscopic drainage aborts endotoxaemia in acute cholangitis
AU - Lau, J. Y W
AU - Ip, S. M.
AU - Chung, S. C S
AU - Leung, Joseph
AU - Ling, T. K W
AU - Yung, M. Y.
AU - Li, A. K C
PY - 1996
Y1 - 1996
N2 - Forty patients with acute calculous cholangitis had successful endoscopic drainage. Bile from nasobiliary drains and venous blood was collected at 0, 12, 24, 36 and 48 h after endoscopy. Endotoxin levels were measured by the chromogenic Limulus Amoebocyte Lysate assay. There was a significant reduction in both bile and serum endotoxin levels after endoscopic drainage (P<0.001). Endotoxaemia occurred when bile endotoxin reached 103 EU/ml and rose exponentially beyond this threshold. Significant association was demonstrated between both bile and serum endotoxins to the clinical features of cholangitis (P < 0.05). No correlation was evident between serum endotoxin and the parameters of white cell count, serum bilirubin and alkaline phosphatase (r=0.53, 0.00 and 0.00 respectively). Endoscopic drainage is effective in lowering bile and serum endotoxin levels and clinical signs and symptoms reliably predict endotoxaemia.
AB - Forty patients with acute calculous cholangitis had successful endoscopic drainage. Bile from nasobiliary drains and venous blood was collected at 0, 12, 24, 36 and 48 h after endoscopy. Endotoxin levels were measured by the chromogenic Limulus Amoebocyte Lysate assay. There was a significant reduction in both bile and serum endotoxin levels after endoscopic drainage (P<0.001). Endotoxaemia occurred when bile endotoxin reached 103 EU/ml and rose exponentially beyond this threshold. Significant association was demonstrated between both bile and serum endotoxins to the clinical features of cholangitis (P < 0.05). No correlation was evident between serum endotoxin and the parameters of white cell count, serum bilirubin and alkaline phosphatase (r=0.53, 0.00 and 0.00 respectively). Endoscopic drainage is effective in lowering bile and serum endotoxin levels and clinical signs and symptoms reliably predict endotoxaemia.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030051790&partnerID=8YFLogxK
U2 - 10.1002/bjs.1800830210
DO - 10.1002/bjs.1800830210
M3 - Article
C2 - 8689158
AN - SCOPUS:0030051790
VL - 83
SP - 181
EP - 184
JO - British Journal of Surgery
JF - British Journal of Surgery
SN - 0007-1323
IS - 2
ER -