Abstract
We explore autofluorescence endomicroscopy as a potential tool for real-time visualization of epithelial tissue microstructure and organization in a clinical setting. The design parameters are explored using two experimental systems - an Olympus Medical Systems Corp. stand-alone clinical prototype probe, and a custom built bench-top rigid fiber conduit prototype. Both systems entail ultraviolet excitation at 266 nm and/or 325 nm using compact laser sources. Preliminary results using ex vivo animal and human tissue specimens suggest that this technology can be translated toward in vivo application to address the need for real-time histology.
| Original language | English (US) |
|---|---|
| Article number | 046014 |
| Journal | Journal of Biomedical Optics |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2011 |
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Keywords
- Endomicroscopy
- Real-time histology
- Ultraviolet autofluorescence
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
Cite this
Endomicroscopy imaging of epithelial structures using tissue autofluorescence. / Lin, Bevin; Urayama, Shiro; Saroufeem, Ramez M G; Matthews, Dennis L; Demos, Stavros G.
In: Journal of Biomedical Optics, Vol. 16, No. 4, 046014, 04.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endomicroscopy imaging of epithelial structures using tissue autofluorescence
AU - Lin, Bevin
AU - Urayama, Shiro
AU - Saroufeem, Ramez M G
AU - Matthews, Dennis L
AU - Demos, Stavros G.
PY - 2011/4
Y1 - 2011/4
N2 - We explore autofluorescence endomicroscopy as a potential tool for real-time visualization of epithelial tissue microstructure and organization in a clinical setting. The design parameters are explored using two experimental systems - an Olympus Medical Systems Corp. stand-alone clinical prototype probe, and a custom built bench-top rigid fiber conduit prototype. Both systems entail ultraviolet excitation at 266 nm and/or 325 nm using compact laser sources. Preliminary results using ex vivo animal and human tissue specimens suggest that this technology can be translated toward in vivo application to address the need for real-time histology.
AB - We explore autofluorescence endomicroscopy as a potential tool for real-time visualization of epithelial tissue microstructure and organization in a clinical setting. The design parameters are explored using two experimental systems - an Olympus Medical Systems Corp. stand-alone clinical prototype probe, and a custom built bench-top rigid fiber conduit prototype. Both systems entail ultraviolet excitation at 266 nm and/or 325 nm using compact laser sources. Preliminary results using ex vivo animal and human tissue specimens suggest that this technology can be translated toward in vivo application to address the need for real-time histology.
KW - Endomicroscopy
KW - Real-time histology
KW - Ultraviolet autofluorescence
UR - http://www.scopus.com/inward/record.url?scp=80455163277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80455163277&partnerID=8YFLogxK
U2 - 10.1117/1.3565216
DO - 10.1117/1.3565216
M3 - Article
VL - 16
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 4
M1 - 046014
ER -