Endometrial thickness after misoprostol use for early pregnancy failure

Mitchell D Creinin, B. Harwood, R. S. Guido, M. C. Fox, J. Zhang

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objectives: To assess if there was any potential relationship between endometrial thickness and final treatment outcome in women successfully treated with misoprostol for a first trimester anembryonic gestation, embryonic demise or fetal demise. Methods: Eighty women were treated with up to two doses of misoprostol 800 μg vaginally for early pregnancy failure. Subjects were scheduled to return 2 (range 1-4), 7 (range 5-9) and 14 (range 12-17) days after treatment. Transvaginal ultrasonography was performed at each follow-up visit. Results: The median endometrial thickness at each of the follow-up visits for women who had expelled the gestational sac was 14 mm, 10 mm, and 7 mm, respectively. The endometrial thickness at the first follow-up visit exceeded 15 mm in 20 subjects (36%) and 30 mm in four subjects (7%). Only three women had a suction aspiration for bleeding after documented expulsion. The endometrial thickness for these women was 11, 13, and 14 mm at the first follow-up visit. Conclusions: There is no obvious relationship between increasing endometrial thickness and the need for surgical intervention in women treated with misoprostol for early pregnancy failure.

Original languageEnglish (US)
Pages (from-to)22-26
Number of pages5
JournalInternational Journal of Gynecology and Obstetrics
Volume86
Issue number1
DOIs
StatePublished - Jul 2004
Externally publishedYes

Fingerprint

Misoprostol
Pregnancy
Gestational Sac
Fetal Death
Suction
First Pregnancy Trimester
Ultrasonography
Hemorrhage

Keywords

  • Early pregnancy failure
  • endometrial thickness
  • Miscarriage
  • Misoprostol
  • Transvaginal ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Endometrial thickness after misoprostol use for early pregnancy failure. / Creinin, Mitchell D; Harwood, B.; Guido, R. S.; Fox, M. C.; Zhang, J.

In: International Journal of Gynecology and Obstetrics, Vol. 86, No. 1, 07.2004, p. 22-26.

Research output: Contribution to journalArticle

Creinin, Mitchell D ; Harwood, B. ; Guido, R. S. ; Fox, M. C. ; Zhang, J. / Endometrial thickness after misoprostol use for early pregnancy failure. In: International Journal of Gynecology and Obstetrics. 2004 ; Vol. 86, No. 1. pp. 22-26.
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