Endometrial leukocyte subpopulations associated with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis genital tract infection

Seth D. Reighard, Richard L Sweet, Claudia Vicetti Miguel, Rodolfo D. Vicetti Miguel, Mamatha Chivukula, Uma Krishnamurti, Thomas L. Cherpes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVE: The objective of the study was to characterize endometrial inflammation associated with common genital tract pathogens. STUDY DESIGN: The design of the study was the immunohistochemical characterization of the endometrial leukocyte subpopulations from 37 controls and 45 women infected with Chlamydia trachomatis, Neisseria gonorrhoeae, or Trichomonas vaginalis. RESULTS: Compared with uninfected women, endocervical infection with C trachomatis, N gonorrhoeae, or T vaginalis was associated with significant increases in endometrial T cells, B cells, plasma cells, and polymorphonuclear leukocytes. Even more substantial increases in T cell, B cell, and plasma cell numbers were detected among women infected endocervically and endometrially with C trachomatis. CONCLUSION: Because lower genital tract C trachomatis, N gonorrhoeae, or T vaginalis infections were associated with comparable increases in the same endometrial leukocyte subpopulations, our results suggest the underappreciated involvement of T vaginalis in upper genital tract inflammatory processes. The more robust inflammatory infiltrate associated with C trachomatis endometrial ascension may offer insight into host inflammatory responses associated with pelvic inflammatory disease development.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume205
Issue number4
DOIs
StatePublished - Oct 2011

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Reproductive Tract Infections
Trichomonas vaginalis
Neisseria gonorrhoeae
Chlamydia trachomatis
Leukocytes
Gonorrhea
Plasma Cells
B-Lymphocytes
T-Lymphocytes
Pelvic Inflammatory Disease
Infection
Neutrophils
Cell Count
Inflammation

Keywords

  • Chlamydia trachomatis
  • Endometritis
  • Neisseria gonorrhoeae
  • Pelvic inflammatory disease
  • Trichomonas vaginalis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Endometrial leukocyte subpopulations associated with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis genital tract infection. / Reighard, Seth D.; Sweet, Richard L; Vicetti Miguel, Claudia; Vicetti Miguel, Rodolfo D.; Chivukula, Mamatha; Krishnamurti, Uma; Cherpes, Thomas L.

In: American Journal of Obstetrics and Gynecology, Vol. 205, No. 4, 10.2011.

Research output: Contribution to journalArticle

Reighard, Seth D. ; Sweet, Richard L ; Vicetti Miguel, Claudia ; Vicetti Miguel, Rodolfo D. ; Chivukula, Mamatha ; Krishnamurti, Uma ; Cherpes, Thomas L. / Endometrial leukocyte subpopulations associated with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis genital tract infection. In: American Journal of Obstetrics and Gynecology. 2011 ; Vol. 205, No. 4.
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