Endogenous Retroviral Envelope Syncytin Induces HIV-1 Spreading and Establishes HIV Reservoirs in Placenta

Yuyang Tang, Beverly O. Woodward, Lorena Pastor, Alvin M. George, Oksana Petrechko, Franklin J. Nouvet, David W. Haas, Guochun Jiang, James E.K. Hildreth

Research output: Contribution to journalArticle

Abstract

Tang et al. report that syncytin, the envelope glycoprotein of human endogenous retrovirus family W1, facilitates HIV infection in trophoblasts by cell-to-cell fusion. This mechanism of HIV entry helps the virus overcome the placental barrier for infection in deep tissues.

Original languageEnglish (US)
Pages (from-to)4528-4539.e4
JournalCell Reports
Volume30
Issue number13
DOIs
StatePublished - Mar 31 2020

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Tang, Y., Woodward, B. O., Pastor, L., George, A. M., Petrechko, O., Nouvet, F. J., Haas, D. W., Jiang, G., & Hildreth, J. E. K. (2020). Endogenous Retroviral Envelope Syncytin Induces HIV-1 Spreading and Establishes HIV Reservoirs in Placenta. Cell Reports, 30(13), 4528-4539.e4. https://doi.org/10.1016/j.celrep.2020.03.016