Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy

Giuseppe Biagini, Enrica Baldelli, Daniela Longo, Luca Pradelli, Isabella Zini, Michael A Rogawski, Massimo Avoli

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis is unknown. Status epilepticus (SE) induces temporal lobe epileptogenesis following a latent period in which glial cells are activated. Here, we found that P450scc, the rate-limiting enzyme in steroid synthesis, is upregulated in hippocampal glia during the latent period after pilocarpine-induced SE in rats. More prolonged SE was associated with greater P450scc expression and longer latencies to the development of seizures, suggesting that enhanced steroid synthesis retards epileptogenesis. The 5α-reductase inhibitor finasteride, which blocks neurosteroid synthesis, reduced the latent period, indicating that glia-derived neurosteroids may be antiepileptogenic.

Original languageEnglish (US)
Pages (from-to)519-524
Number of pages6
JournalExperimental Neurology
Volume201
Issue number2
DOIs
StatePublished - Oct 2006
Externally publishedYes

Keywords

  • Epileptogenesis
  • Glia
  • Hippocampus
  • Neurosteroid
  • Pilocarpine
  • Status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

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