Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy

Giuseppe Biagini, Enrica Baldelli, Daniela Longo, Luca Pradelli, Isabella Zini, Michael A Rogawski, Massimo Avoli

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis is unknown. Status epilepticus (SE) induces temporal lobe epileptogenesis following a latent period in which glial cells are activated. Here, we found that P450scc, the rate-limiting enzyme in steroid synthesis, is upregulated in hippocampal glia during the latent period after pilocarpine-induced SE in rats. More prolonged SE was associated with greater P450scc expression and longer latencies to the development of seizures, suggesting that enhanced steroid synthesis retards epileptogenesis. The 5α-reductase inhibitor finasteride, which blocks neurosteroid synthesis, reduced the latent period, indicating that glia-derived neurosteroids may be antiepileptogenic.

Original languageEnglish (US)
Pages (from-to)519-524
Number of pages6
JournalExperimental Neurology
Volume201
Issue number2
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Temporal Lobe Epilepsy
Status Epilepticus
Neuroglia
Neurotransmitter Agents
Seizures
Steroids
Finasteride
Pilocarpine
Temporal Lobe
Oxidoreductases
Enzymes

Keywords

  • Epileptogenesis
  • Glia
  • Hippocampus
  • Neurosteroid
  • Pilocarpine
  • Status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy. / Biagini, Giuseppe; Baldelli, Enrica; Longo, Daniela; Pradelli, Luca; Zini, Isabella; Rogawski, Michael A; Avoli, Massimo.

In: Experimental Neurology, Vol. 201, No. 2, 10.2006, p. 519-524.

Research output: Contribution to journalArticle

Biagini, Giuseppe ; Baldelli, Enrica ; Longo, Daniela ; Pradelli, Luca ; Zini, Isabella ; Rogawski, Michael A ; Avoli, Massimo. / Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy. In: Experimental Neurology. 2006 ; Vol. 201, No. 2. pp. 519-524.
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