Endogenous Myc maintains the tumor microenvironment

Nicole M. Sodir, Lamorna Brown Swigart, Anthony Karnezis, Douglas Hanahan, Gerard I. Evan, Laura Soucek

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

The ubiquitous deregulation of Myc in human cancers makes it an intriguing therapeutic target, a notion supported by recent studies in Ras-driven lung tumors showing that inhibiting endogenous Myc triggers ubiquitous tumor regression. However, neither the therapeutic mechanism nor the applicability of Myc inhibition to other tumor types driven by other oncogenic mechanisms is established. Here, we show that inhibition of endogenous Myc also triggers ubiquitous regression of tumors in a simian virus 40 (SV40)-driven pancreatic islet tumor model. Such regression is presaged by collapse of the tumor microenvironment and involution of tumor vasculature. Hence, in addition to its diverse intracellular roles, endogenous Myc serves an essential and nonredundant role in coupling diverse intracellular oncogenic pathways to the tumor microenvironment, further bolstering its credentials as a pharmacological target.

Original languageEnglish (US)
Pages (from-to)907-916
Number of pages10
JournalGenes and Development
Volume25
Issue number9
DOIs
StatePublished - May 1 2011
Externally publishedYes

Keywords

  • Microenvironment
  • Myc inhibition
  • Pancreas
  • Therapeutics
  • Tumor

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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    Sodir, N. M., Swigart, L. B., Karnezis, A., Hanahan, D., Evan, G. I., & Soucek, L. (2011). Endogenous Myc maintains the tumor microenvironment. Genes and Development, 25(9), 907-916. https://doi.org/10.1101/gad.2038411