Endogenous galectin-3 controls experimental malaria in a species-specific manner

M. A. Toscano, J. E. Tongren, J. B. De Souza, Fu-Tong Liu, E. M. Riley, G. A. Rabinovich

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host-pathogen interactions, the relevance of this lectin in the regulation of the host defence mechanisms in vivo is poorly understood. In this study, we analysed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, Plasmodium yoelii 17XNL, Plasmodium berghei ANKA and Plasmodium chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3 -/- mice was consistent with higher titres of anti-P. yoelii MSP1 19 IgG2b isotype antibodies when compared with their wild-type counterparts. Our results reflect the complexity and singularity of host-pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalParasite Immunology
Volume34
Issue number7
DOIs
StatePublished - Jul 2012

Fingerprint

Galectin 3
Malaria
Parasitemia
Plasmodium yoelii
Plasmodium chabaudi
Host-Pathogen Interactions
Plasmodium berghei
Merozoite Surface Protein 1
Galectins
Parasitic Diseases
Adaptive Immunity
Lectins
Innate Immunity
Antibody Formation
Polysaccharides
Rodentia
Carrier Proteins
Parasites
Antibodies
Infection

Keywords

  • Galectin-3
  • Immunoglobulin G
  • Plasmodium spp.

ASJC Scopus subject areas

  • Parasitology
  • Immunology

Cite this

Toscano, M. A., Tongren, J. E., De Souza, J. B., Liu, F-T., Riley, E. M., & Rabinovich, G. A. (2012). Endogenous galectin-3 controls experimental malaria in a species-specific manner. Parasite Immunology, 34(7), 383-387. https://doi.org/10.1111/j.1365-3024.2012.01366.x

Endogenous galectin-3 controls experimental malaria in a species-specific manner. / Toscano, M. A.; Tongren, J. E.; De Souza, J. B.; Liu, Fu-Tong; Riley, E. M.; Rabinovich, G. A.

In: Parasite Immunology, Vol. 34, No. 7, 07.2012, p. 383-387.

Research output: Contribution to journalArticle

Toscano, MA, Tongren, JE, De Souza, JB, Liu, F-T, Riley, EM & Rabinovich, GA 2012, 'Endogenous galectin-3 controls experimental malaria in a species-specific manner', Parasite Immunology, vol. 34, no. 7, pp. 383-387. https://doi.org/10.1111/j.1365-3024.2012.01366.x
Toscano MA, Tongren JE, De Souza JB, Liu F-T, Riley EM, Rabinovich GA. Endogenous galectin-3 controls experimental malaria in a species-specific manner. Parasite Immunology. 2012 Jul;34(7):383-387. https://doi.org/10.1111/j.1365-3024.2012.01366.x
Toscano, M. A. ; Tongren, J. E. ; De Souza, J. B. ; Liu, Fu-Tong ; Riley, E. M. ; Rabinovich, G. A. / Endogenous galectin-3 controls experimental malaria in a species-specific manner. In: Parasite Immunology. 2012 ; Vol. 34, No. 7. pp. 383-387.
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