Endogenous electric currents might guide rostral migration of neuroblasts

Lin Cao, Dongguang Wei, Brian Reid, Siwei Zhao, Jin Pu, Tingrui Pan, Ebenezer N. Yamoah, Min Zhao

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm2, average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.

Original languageEnglish (US)
Pages (from-to)184-190
Number of pages7
JournalEMBO Reports
Volume14
Issue number2
DOIs
StatePublished - Feb 2013

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Lateral Ventricles
Electric currents
Purinergic P2Y1 Receptors
Brain
Cues
Electric fields

Keywords

  • electric field
  • electrical corridors
  • neuroblast
  • purinergic receptor
  • rostral migration

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

Cite this

Endogenous electric currents might guide rostral migration of neuroblasts. / Cao, Lin; Wei, Dongguang; Reid, Brian; Zhao, Siwei; Pu, Jin; Pan, Tingrui; Yamoah, Ebenezer N.; Zhao, Min.

In: EMBO Reports, Vol. 14, No. 2, 02.2013, p. 184-190.

Research output: Contribution to journalArticle

Cao, Lin ; Wei, Dongguang ; Reid, Brian ; Zhao, Siwei ; Pu, Jin ; Pan, Tingrui ; Yamoah, Ebenezer N. ; Zhao, Min. / Endogenous electric currents might guide rostral migration of neuroblasts. In: EMBO Reports. 2013 ; Vol. 14, No. 2. pp. 184-190.
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