Endocrinology of a Single Cell: Tools and Insights

Hanna Pincas; Frederique Ruf-Zamojski; Judith L. Turgeon; Stuart C. Sealfon

doi:10.1016/B978-0-12-819801-8.00001-6

Endocrinology of a Single Cell: Tools and Insights

Hanna Pincas, Frederique Ruf-Zamojski, Judith L. Turgeon, Stuart C. Sealfon

Endocrinology, Diabetes, and Metabolism

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Recent advances in single-cell (SC) technologies have enabled scientists to gain groundbreaking insights into cellular diversity, cell development, and cellular dynamics. In this chapter, we review recent SC technologies that address the key questions in the field of endocrine research, including characterization of cellular heterogeneity within a tissue, molecular classification of endocrine tumors, and analysis of signaling dynamics and stimulus response, such as hormone secretion. We provide examples of SC studies and highlight their main findings, focusing on recent discoveries on pancreatic β-cells and pituitary gonadotropes. Lastly, we discuss the pitfalls and limitations of SC approaches, as well as future avenues of research and technology development in this rapidly evolving field.

Original language	English (US)
Title of host publication	Cellular Endocrinology in Health and Disease, Second Edition
Publisher	Elsevier
Pages	1-25
Number of pages	25
ISBN (Electronic)	9780128198018
DOIs	https://doi.org/10.1016/B978-0-12-819801-8.00001-6
State	Published - Jan 1 2021

Keywords

Cell state
Cell type
Development
Endocrine cellsSingle-cell analysis
Pancreatic β-cell
Pituitary gonadotrope
Transdifferentiation

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/B978-0-12-819801-8.00001-6

Cite this

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Endocrinology of a Single Cell: Tools and Insights

Abstract

Keywords

ASJC Scopus subject areas

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