Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women

Influence of insulin resistance on plasma triglyceride responses

Karen L. Teff, Joanne Grudziak, Raymond R. Townsend, Tamara N. Dunn, Ryan W. Grant, Sean H. Adams, Nancy L. Keim, Bethany P. Cummings, Kimber Stanhope, Peter J Havel

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

Context: Compared with glucose-sweetened beverages, consumption of fructose-sweetened beverages with meals elevates postprandial plasma triglycerides and lowers 24-h insulin and leptin profiles in normal-weight women. The effects of fructose, compared with glucose, ingestion on metabolic profiles in obese subjects has not been studied. Objective: The objective of the study was to compare the effects of fructose- and glucose-sweetened beverages consumed with meals on hormones and metabolic substrates in obese subjects. Design and Setting: The study had a within-subject design conducted in the clinical and translational research center. Participants: Participants included 17 obese men (n = 9) and women (n = 8), with a body mass index greater than 30 kg/m2. Interventions: Subjects were studied under two conditions involving ingestion of mixed nutrient meals with either glucose-sweetened beverages or fructose-sweetened beverages. The beverages provided 30% of total kilocalories. Blood samples were collected over 24 h. Main Outcome Measures: Area under the curve (24 h AUC) for glucose, lactate, insulin, leptin, ghrelin, uric acid, triglycerides (TGs), and free fatty acids was measured. Results: Compared with glucose-sweetened beverages, fructose consumption was associated with lower AUCs for insulin (1052.6 ± 135.1 vs. 549.2 ± 79.7 μU/ml per 23 h, P < 0.001) and leptin (151.9 ± 22.7 vs. 107.0 ± 15.0 ng/ml per 24 h, P < 0.03) and increased AUC for TG (242.3 ± 96.8 vs. 704.3 ± 124.4 mg/dl per 24 h, P < 0.0001). Insulin-resistant subjects exhibited larger 24-h TG profiles (P < 0.03). Conclusions: In obese subjects, consumption of fructose-sweetened beverages with meals was associated with less insulin secretion, blunted diurnal leptin profiles, and increased postprandial TG concentrations compared with glucose consumption. Increases of TGs were augmented in obese subjects with insulin resistance, suggesting that fructose consumption may exacerbate an already adverse metabolic profile present in many obese subjects.

Original languageEnglish (US)
Pages (from-to)1562-1569
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number5
DOIs
StatePublished - May 2009

Fingerprint

Beverages
Fructose
Meals
Insulin Resistance
Triglycerides
Insulin
Plasmas
Glucose
Leptin
Area Under Curve
Metabolome
Eating
Ghrelin
Translational Medical Research
Uric Acid
Nonesterified Fatty Acids
Nutrients
Lactic Acid
Body Mass Index
Blood

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women : Influence of insulin resistance on plasma triglyceride responses. / Teff, Karen L.; Grudziak, Joanne; Townsend, Raymond R.; Dunn, Tamara N.; Grant, Ryan W.; Adams, Sean H.; Keim, Nancy L.; Cummings, Bethany P.; Stanhope, Kimber; Havel, Peter J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 5, 05.2009, p. 1562-1569.

Research output: Contribution to journalArticle

Teff, Karen L. ; Grudziak, Joanne ; Townsend, Raymond R. ; Dunn, Tamara N. ; Grant, Ryan W. ; Adams, Sean H. ; Keim, Nancy L. ; Cummings, Bethany P. ; Stanhope, Kimber ; Havel, Peter J. / Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women : Influence of insulin resistance on plasma triglyceride responses. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 5. pp. 1562-1569.
@article{4746b91496b144d9a372c3ea18a87a28,
title = "Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: Influence of insulin resistance on plasma triglyceride responses",
abstract = "Context: Compared with glucose-sweetened beverages, consumption of fructose-sweetened beverages with meals elevates postprandial plasma triglycerides and lowers 24-h insulin and leptin profiles in normal-weight women. The effects of fructose, compared with glucose, ingestion on metabolic profiles in obese subjects has not been studied. Objective: The objective of the study was to compare the effects of fructose- and glucose-sweetened beverages consumed with meals on hormones and metabolic substrates in obese subjects. Design and Setting: The study had a within-subject design conducted in the clinical and translational research center. Participants: Participants included 17 obese men (n = 9) and women (n = 8), with a body mass index greater than 30 kg/m2. Interventions: Subjects were studied under two conditions involving ingestion of mixed nutrient meals with either glucose-sweetened beverages or fructose-sweetened beverages. The beverages provided 30{\%} of total kilocalories. Blood samples were collected over 24 h. Main Outcome Measures: Area under the curve (24 h AUC) for glucose, lactate, insulin, leptin, ghrelin, uric acid, triglycerides (TGs), and free fatty acids was measured. Results: Compared with glucose-sweetened beverages, fructose consumption was associated with lower AUCs for insulin (1052.6 ± 135.1 vs. 549.2 ± 79.7 μU/ml per 23 h, P < 0.001) and leptin (151.9 ± 22.7 vs. 107.0 ± 15.0 ng/ml per 24 h, P < 0.03) and increased AUC for TG (242.3 ± 96.8 vs. 704.3 ± 124.4 mg/dl per 24 h, P < 0.0001). Insulin-resistant subjects exhibited larger 24-h TG profiles (P < 0.03). Conclusions: In obese subjects, consumption of fructose-sweetened beverages with meals was associated with less insulin secretion, blunted diurnal leptin profiles, and increased postprandial TG concentrations compared with glucose consumption. Increases of TGs were augmented in obese subjects with insulin resistance, suggesting that fructose consumption may exacerbate an already adverse metabolic profile present in many obese subjects.",
author = "Teff, {Karen L.} and Joanne Grudziak and Townsend, {Raymond R.} and Dunn, {Tamara N.} and Grant, {Ryan W.} and Adams, {Sean H.} and Keim, {Nancy L.} and Cummings, {Bethany P.} and Kimber Stanhope and Havel, {Peter J}",
year = "2009",
month = "5",
doi = "10.1210/jc.2008-2192",
language = "English (US)",
volume = "94",
pages = "1562--1569",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "5",

}

TY - JOUR

T1 - Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women

T2 - Influence of insulin resistance on plasma triglyceride responses

AU - Teff, Karen L.

AU - Grudziak, Joanne

AU - Townsend, Raymond R.

AU - Dunn, Tamara N.

AU - Grant, Ryan W.

AU - Adams, Sean H.

AU - Keim, Nancy L.

AU - Cummings, Bethany P.

AU - Stanhope, Kimber

AU - Havel, Peter J

PY - 2009/5

Y1 - 2009/5

N2 - Context: Compared with glucose-sweetened beverages, consumption of fructose-sweetened beverages with meals elevates postprandial plasma triglycerides and lowers 24-h insulin and leptin profiles in normal-weight women. The effects of fructose, compared with glucose, ingestion on metabolic profiles in obese subjects has not been studied. Objective: The objective of the study was to compare the effects of fructose- and glucose-sweetened beverages consumed with meals on hormones and metabolic substrates in obese subjects. Design and Setting: The study had a within-subject design conducted in the clinical and translational research center. Participants: Participants included 17 obese men (n = 9) and women (n = 8), with a body mass index greater than 30 kg/m2. Interventions: Subjects were studied under two conditions involving ingestion of mixed nutrient meals with either glucose-sweetened beverages or fructose-sweetened beverages. The beverages provided 30% of total kilocalories. Blood samples were collected over 24 h. Main Outcome Measures: Area under the curve (24 h AUC) for glucose, lactate, insulin, leptin, ghrelin, uric acid, triglycerides (TGs), and free fatty acids was measured. Results: Compared with glucose-sweetened beverages, fructose consumption was associated with lower AUCs for insulin (1052.6 ± 135.1 vs. 549.2 ± 79.7 μU/ml per 23 h, P < 0.001) and leptin (151.9 ± 22.7 vs. 107.0 ± 15.0 ng/ml per 24 h, P < 0.03) and increased AUC for TG (242.3 ± 96.8 vs. 704.3 ± 124.4 mg/dl per 24 h, P < 0.0001). Insulin-resistant subjects exhibited larger 24-h TG profiles (P < 0.03). Conclusions: In obese subjects, consumption of fructose-sweetened beverages with meals was associated with less insulin secretion, blunted diurnal leptin profiles, and increased postprandial TG concentrations compared with glucose consumption. Increases of TGs were augmented in obese subjects with insulin resistance, suggesting that fructose consumption may exacerbate an already adverse metabolic profile present in many obese subjects.

AB - Context: Compared with glucose-sweetened beverages, consumption of fructose-sweetened beverages with meals elevates postprandial plasma triglycerides and lowers 24-h insulin and leptin profiles in normal-weight women. The effects of fructose, compared with glucose, ingestion on metabolic profiles in obese subjects has not been studied. Objective: The objective of the study was to compare the effects of fructose- and glucose-sweetened beverages consumed with meals on hormones and metabolic substrates in obese subjects. Design and Setting: The study had a within-subject design conducted in the clinical and translational research center. Participants: Participants included 17 obese men (n = 9) and women (n = 8), with a body mass index greater than 30 kg/m2. Interventions: Subjects were studied under two conditions involving ingestion of mixed nutrient meals with either glucose-sweetened beverages or fructose-sweetened beverages. The beverages provided 30% of total kilocalories. Blood samples were collected over 24 h. Main Outcome Measures: Area under the curve (24 h AUC) for glucose, lactate, insulin, leptin, ghrelin, uric acid, triglycerides (TGs), and free fatty acids was measured. Results: Compared with glucose-sweetened beverages, fructose consumption was associated with lower AUCs for insulin (1052.6 ± 135.1 vs. 549.2 ± 79.7 μU/ml per 23 h, P < 0.001) and leptin (151.9 ± 22.7 vs. 107.0 ± 15.0 ng/ml per 24 h, P < 0.03) and increased AUC for TG (242.3 ± 96.8 vs. 704.3 ± 124.4 mg/dl per 24 h, P < 0.0001). Insulin-resistant subjects exhibited larger 24-h TG profiles (P < 0.03). Conclusions: In obese subjects, consumption of fructose-sweetened beverages with meals was associated with less insulin secretion, blunted diurnal leptin profiles, and increased postprandial TG concentrations compared with glucose consumption. Increases of TGs were augmented in obese subjects with insulin resistance, suggesting that fructose consumption may exacerbate an already adverse metabolic profile present in many obese subjects.

UR - http://www.scopus.com/inward/record.url?scp=66149120712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149120712&partnerID=8YFLogxK

U2 - 10.1210/jc.2008-2192

DO - 10.1210/jc.2008-2192

M3 - Article

VL - 94

SP - 1562

EP - 1569

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -