Endemic malaria in the Peruvian Amazon region of Iquitos.

Baback Roshanravan, Elina Kari, Robert H. Gilman, Lilia Cabrera, Ellen Lee, John Metcalfe, Maritza Calderon, Andres G. Lescano, Sonia H. Montenegro, Carlos Calampa, Joseph M. Vinetz

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

A cross-sectional study was conducted in the Peruvian Amazon to test the hypothesis that a reservoir of asymptomatic malaria parasitemic patients would form the basis for continuing malaria endemicity in the region. Active surveillance yielded a Plasmodium spp. slide-positive prevalence of 4.2% (43 of 1,023) and a polymerase chain reaction (PCR)-positive prevalence of 17.6% (144 of 819). Plasmodium vivax prevalence was 2.9% and 14.2% while Plasmodium falciparum prevalence was 1.3% and 2.6% by microscopy and PCR, respectively. Approximately two-thirds of slide-positive and one-fourth of PCR-positive people were symptomatic. Anemia was associated with slide positivity (P < 0.001) and PCR positivity for P. falciparum (P = 0.003). Sensitivity of field microscopy and agreement between field and reference laboratory microscopists were low, arguing for using PCR for epidemiologic investigation and malaria control. While these data confirm recent findings from the Brazilian Amazon suggesting that sufficient numbers of asymptomatic malaria parasitemic patients are present to form a persistent reservoir for continuous reinfection within the Peruvian Amazon region, these results also indicate that clinical immunity in human populations can be driven in malaria-endemic regions that do not have high intensity malaria transmission.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalThe American journal of tropical medicine and hygiene
Volume69
Issue number1
StatePublished - Jul 2003
Externally publishedYes

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Malaria
Polymerase Chain Reaction
Plasmodium falciparum
Microscopy
Plasmodium vivax
Plasmodium
Anemia
Immunity
Cross-Sectional Studies
Population

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Roshanravan, B., Kari, E., Gilman, R. H., Cabrera, L., Lee, E., Metcalfe, J., ... Vinetz, J. M. (2003). Endemic malaria in the Peruvian Amazon region of Iquitos. The American journal of tropical medicine and hygiene, 69(1), 45-52.

Endemic malaria in the Peruvian Amazon region of Iquitos. / Roshanravan, Baback; Kari, Elina; Gilman, Robert H.; Cabrera, Lilia; Lee, Ellen; Metcalfe, John; Calderon, Maritza; Lescano, Andres G.; Montenegro, Sonia H.; Calampa, Carlos; Vinetz, Joseph M.

In: The American journal of tropical medicine and hygiene, Vol. 69, No. 1, 07.2003, p. 45-52.

Research output: Contribution to journalArticle

Roshanravan, B, Kari, E, Gilman, RH, Cabrera, L, Lee, E, Metcalfe, J, Calderon, M, Lescano, AG, Montenegro, SH, Calampa, C & Vinetz, JM 2003, 'Endemic malaria in the Peruvian Amazon region of Iquitos.', The American journal of tropical medicine and hygiene, vol. 69, no. 1, pp. 45-52.
Roshanravan, Baback ; Kari, Elina ; Gilman, Robert H. ; Cabrera, Lilia ; Lee, Ellen ; Metcalfe, John ; Calderon, Maritza ; Lescano, Andres G. ; Montenegro, Sonia H. ; Calampa, Carlos ; Vinetz, Joseph M. / Endemic malaria in the Peruvian Amazon region of Iquitos. In: The American journal of tropical medicine and hygiene. 2003 ; Vol. 69, No. 1. pp. 45-52.
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