End-stage renal disease from glomerulonephritis associated with anti-phospholipid syndrome

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8 Scopus citations


Primary anti-phospholipid syndrome (APS) is perceived to be an uncommon disorder, infrequently recognized as a cause of renal disease in childhood. While renal involvement in APS classically manifests as thrombotic events, other renal diseases associated with APS have been reported in adults, including membranous nephropathy and minimal change disease. We report our experience of caring for a child who presented with acute anuric renal failure due to anti-neutrophilic cytoplasmic antibody-negative rapidly progressive glomerulonephritis (RPGN), with concomitant thrombotic microangiopathy (TMA). Recognition of the APS as a cause of the patient's TMA facilitated institution of anticoagulation. Our patient's renal failure did not improve and the patient remained dependent on dialysis until he was successfully transplanted. The purpose of our report is to make health-care professionals aware of the previously unreported association of pauci-immune RPGN and APS in children; early recognition of APS will allow initiation of anticoagulation to prevent recurrent thromboses and enable successful transplantation.

Original languageEnglish (US)
Pages (from-to)812-814
Number of pages3
JournalPediatric Nephrology
Issue number7
StatePublished - Jul 2004


  • Anti-phospholipid syndrome
  • Chronic renal failure
  • Lupus anticoagulant
  • Rapidly progressive glomerulonephritis
  • Thrombotic microangiopathy

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health


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