Abstract
Primary anti-phospholipid syndrome (APS) is perceived to be an uncommon disorder, infrequently recognized as a cause of renal disease in childhood. While renal involvement in APS classically manifests as thrombotic events, other renal diseases associated with APS have been reported in adults, including membranous nephropathy and minimal change disease. We report our experience of caring for a child who presented with acute anuric renal failure due to anti-neutrophilic cytoplasmic antibody-negative rapidly progressive glomerulonephritis (RPGN), with concomitant thrombotic microangiopathy (TMA). Recognition of the APS as a cause of the patient's TMA facilitated institution of anticoagulation. Our patient's renal failure did not improve and the patient remained dependent on dialysis until he was successfully transplanted. The purpose of our report is to make health-care professionals aware of the previously unreported association of pauci-immune RPGN and APS in children; early recognition of APS will allow initiation of anticoagulation to prevent recurrent thromboses and enable successful transplantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 812-814 |
| Number of pages | 3 |
| Journal | Pediatric Nephrology |
| Volume | 19 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2004 |
Fingerprint
Keywords
- Anti-phospholipid syndrome
- Chronic renal failure
- Lupus anticoagulant
- Rapidly progressive glomerulonephritis
- Thrombotic microangiopathy
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health
Cite this
End-stage renal disease from glomerulonephritis associated with anti-phospholipid syndrome. / Butani, Lavjay.
In: Pediatric Nephrology, Vol. 19, No. 7, 07.2004, p. 812-814.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - End-stage renal disease from glomerulonephritis associated with anti-phospholipid syndrome
AU - Butani, Lavjay
PY - 2004/7
Y1 - 2004/7
N2 - Primary anti-phospholipid syndrome (APS) is perceived to be an uncommon disorder, infrequently recognized as a cause of renal disease in childhood. While renal involvement in APS classically manifests as thrombotic events, other renal diseases associated with APS have been reported in adults, including membranous nephropathy and minimal change disease. We report our experience of caring for a child who presented with acute anuric renal failure due to anti-neutrophilic cytoplasmic antibody-negative rapidly progressive glomerulonephritis (RPGN), with concomitant thrombotic microangiopathy (TMA). Recognition of the APS as a cause of the patient's TMA facilitated institution of anticoagulation. Our patient's renal failure did not improve and the patient remained dependent on dialysis until he was successfully transplanted. The purpose of our report is to make health-care professionals aware of the previously unreported association of pauci-immune RPGN and APS in children; early recognition of APS will allow initiation of anticoagulation to prevent recurrent thromboses and enable successful transplantation.
AB - Primary anti-phospholipid syndrome (APS) is perceived to be an uncommon disorder, infrequently recognized as a cause of renal disease in childhood. While renal involvement in APS classically manifests as thrombotic events, other renal diseases associated with APS have been reported in adults, including membranous nephropathy and minimal change disease. We report our experience of caring for a child who presented with acute anuric renal failure due to anti-neutrophilic cytoplasmic antibody-negative rapidly progressive glomerulonephritis (RPGN), with concomitant thrombotic microangiopathy (TMA). Recognition of the APS as a cause of the patient's TMA facilitated institution of anticoagulation. Our patient's renal failure did not improve and the patient remained dependent on dialysis until he was successfully transplanted. The purpose of our report is to make health-care professionals aware of the previously unreported association of pauci-immune RPGN and APS in children; early recognition of APS will allow initiation of anticoagulation to prevent recurrent thromboses and enable successful transplantation.
KW - Anti-phospholipid syndrome
KW - Chronic renal failure
KW - Lupus anticoagulant
KW - Rapidly progressive glomerulonephritis
KW - Thrombotic microangiopathy
UR - http://www.scopus.com/inward/record.url?scp=3142671505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3142671505&partnerID=8YFLogxK
U2 - 10.1007/s00467-004-1491-3
DO - 10.1007/s00467-004-1491-3
M3 - Article
VL - 19
SP - 812
EP - 814
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 7
ER -