End-plate electromyography: Use of spectral analysis of end-plate noise

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9 Scopus citations


An automated technique for estimating the channel open time of human end-plate acetylcholine receptors (AChR) is described. The method, which is based on the power spectral analysis of electromyographic end-plate noise, is simple and permits a rapid estimation of the dominant AChR ion channel kinetics. Values of AChR channel open time determined by spectral analysis of end-plate noise in adults (1.23 ± 0.01 ms at 33°C) were consistently shorter than those estimated from the decay phase of extracellularly recorded miniature end-plate potentials. The channel open time extracted from the end- plate noise compared well with that derived from the analysis of in vitro recorded acetylcholine-induced current noise. Therefore, spectral analysis of end-plate noise may provide a good estimation of the kinetics of the human AChR ion channel. The technique is particularly useful in identifying congenital myasthenic syndromes with altered AChR ion channel function.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalMuscle and Nerve
Issue number1
StatePublished - 1997


  • congenital myasthenic syndromes
  • end-plate noise
  • slow channel
  • spectral analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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