Encoding of Multiple Reward-Related Computations in Transient and Sustained High-Frequency Activity in Human OFC

Ignacio Saez, Jack Lin, Arjen Stolk, Edward Chang, Josef Parvizi, Gerwin Schalk, Robert T. Knight, Ming Hsu

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Human orbitofrontal cortex (OFC) has long been implicated in value-based decision making. In recent years, convergent evidence from human and model organisms has further elucidated its role in representing reward-related computations underlying decision making. However, a detailed description of these processes remains elusive due in part to (1) limitations in our ability to observe human OFC neural dynamics at the timescale of decision processes and (2) methodological and interspecies differences that make it challenging to connect human and animal findings or to resolve discrepancies when they arise. Here, we sought to address these challenges by conducting multi-electrode electrocorticography (ECoG) recordings in neurosurgical patients during economic decision making to elucidate the electrophysiological signature, sub-second temporal profile, and anatomical distribution of reward-related computations within human OFC. We found that high-frequency activity (HFA) (70–200 Hz) reflected multiple valuation components grouped in two classes of valuation signals that were dissociable in temporal profile and information content: (1) fast, transient responses reflecting signals associated with choice and outcome processing, including anticipated risk and outcome regret, and (2) sustained responses explicitly encoding what happened in the immediately preceding trial. Anatomically, these responses were widely distributed in partially overlapping networks, including regions in the central OFC (Brodmann areas 11 and 13), which have been consistently implicated in reward processing in animal single-unit studies. Together, these results integrate insights drawn from human and animal studies and provide evidence for a role of human OFC in representing multiple reward computations. Saez et al. carried out intracranial recordings in the OFC of human patients while they played a decision-making task and demonstrate that high-frequency activity in OFC reflects a variety of task-related computations, supporting the idea of a task state representation.

Original languageEnglish (US)
Pages (from-to)2889-2899.e3
JournalCurrent Biology
Volume28
Issue number18
DOIs
StatePublished - Sep 24 2018

Keywords

  • ECoC
  • electrocorticography
  • ERP
  • event-related potential
  • field potential
  • FP
  • HFA
  • high-frequency activity
  • OFC
  • orbitofrontal cortex
  • reward-prediction error
  • RPE

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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