Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection

Alexandra Brower, Kelly M. Homb, Philip Bochsler, Robert Porter, Karen Woods, Sue Ubl, David Krueger, Francine Cigel, Kathy L. Kurth

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Brain tissue from 12 aborted bovine fetuses submitted to the Wisconsin Veterinary Diagnostic Laboratory revealed histologic lesions that consisted of glial nodules and variable degrees of mononuclear inflammation, microhemorrhage, neuronal necrosis, and cerebral cortical cavitation. A diagnosis of Bovine herpesvirus 1 (BHV-1) abortion had been made in all of these cases through multiple testing modalities. Brain tissue from 8 of the 12 fetuses was immunohistochemically stained with a monoclonal antibody specific to BHV-1, and, in 5 fetuses, there was positive intralesional staining of neurons, glial cells, and endothelial cells. This preliminary data suggested that herpesviral infection of brain tissue led to the described neurologic lesions. BHV-1 was then amplified from brain tissue in all 12 of the fetuses and was confirmed by partial sequencing of the thymidine kinase and glycoprotein C genes. To the authors' knowledge, neurologic lesions have not previously been described in BHV-1-infected fetuses, nor has BHV-1 previously been identified in bovine fetal brain tissue. The neurologic histopathology attributed to BHV-1 infection in these cases overlaps with the neurologic lesions produced by Neospora caninum, a common etiologic agent of bovine abortion. Therefore, when bovine fetal neurologic lesions are found, both etiologies should be considered and then distinguished by using additional diagnostic tools.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalJournal of Veterinary Diagnostic Investigation
Volume20
Issue number3
DOIs
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

Aborted Fetus
Bovine Herpesvirus 1
Herpesviridae Infections
Bovine herpesvirus 1
Encephalitis
encephalitis
fetus
nervous system
lesions (animal)
Nervous System
Fetus
cattle
brain
infection
Brain
abortion (animals)
neuroglia
Neuroglia
Neospora
thymidine kinase

Keywords

  • Bovine herpesvirus 1
  • Bovines
  • Encephalitis
  • Fetus
  • Herpesvirus
  • Neospora

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection. / Brower, Alexandra; Homb, Kelly M.; Bochsler, Philip; Porter, Robert; Woods, Karen; Ubl, Sue; Krueger, David; Cigel, Francine; Kurth, Kathy L.

In: Journal of Veterinary Diagnostic Investigation, Vol. 20, No. 3, 01.05.2008, p. 297-303.

Research output: Contribution to journalArticle

Brower, A, Homb, KM, Bochsler, P, Porter, R, Woods, K, Ubl, S, Krueger, D, Cigel, F & Kurth, KL 2008, 'Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection', Journal of Veterinary Diagnostic Investigation, vol. 20, no. 3, pp. 297-303. https://doi.org/10.1177/104063870802000306
Brower, Alexandra ; Homb, Kelly M. ; Bochsler, Philip ; Porter, Robert ; Woods, Karen ; Ubl, Sue ; Krueger, David ; Cigel, Francine ; Kurth, Kathy L. / Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection. In: Journal of Veterinary Diagnostic Investigation. 2008 ; Vol. 20, No. 3. pp. 297-303.
@article{9be479bc264d4799b9139be29d245796,
title = "Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection",
abstract = "Brain tissue from 12 aborted bovine fetuses submitted to the Wisconsin Veterinary Diagnostic Laboratory revealed histologic lesions that consisted of glial nodules and variable degrees of mononuclear inflammation, microhemorrhage, neuronal necrosis, and cerebral cortical cavitation. A diagnosis of Bovine herpesvirus 1 (BHV-1) abortion had been made in all of these cases through multiple testing modalities. Brain tissue from 8 of the 12 fetuses was immunohistochemically stained with a monoclonal antibody specific to BHV-1, and, in 5 fetuses, there was positive intralesional staining of neurons, glial cells, and endothelial cells. This preliminary data suggested that herpesviral infection of brain tissue led to the described neurologic lesions. BHV-1 was then amplified from brain tissue in all 12 of the fetuses and was confirmed by partial sequencing of the thymidine kinase and glycoprotein C genes. To the authors' knowledge, neurologic lesions have not previously been described in BHV-1-infected fetuses, nor has BHV-1 previously been identified in bovine fetal brain tissue. The neurologic histopathology attributed to BHV-1 infection in these cases overlaps with the neurologic lesions produced by Neospora caninum, a common etiologic agent of bovine abortion. Therefore, when bovine fetal neurologic lesions are found, both etiologies should be considered and then distinguished by using additional diagnostic tools.",
keywords = "Bovine herpesvirus 1, Bovines, Encephalitis, Fetus, Herpesvirus, Neospora",
author = "Alexandra Brower and Homb, {Kelly M.} and Philip Bochsler and Robert Porter and Karen Woods and Sue Ubl and David Krueger and Francine Cigel and Kurth, {Kathy L.}",
year = "2008",
month = "5",
day = "1",
doi = "10.1177/104063870802000306",
language = "English (US)",
volume = "20",
pages = "297--303",
journal = "Journal of Veterinary Diagnostic Investigation",
issn = "1040-6387",
publisher = "American Association of Veterinary Laboratory Diagnosticians",
number = "3",

}

TY - JOUR

T1 - Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection

AU - Brower, Alexandra

AU - Homb, Kelly M.

AU - Bochsler, Philip

AU - Porter, Robert

AU - Woods, Karen

AU - Ubl, Sue

AU - Krueger, David

AU - Cigel, Francine

AU - Kurth, Kathy L.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Brain tissue from 12 aborted bovine fetuses submitted to the Wisconsin Veterinary Diagnostic Laboratory revealed histologic lesions that consisted of glial nodules and variable degrees of mononuclear inflammation, microhemorrhage, neuronal necrosis, and cerebral cortical cavitation. A diagnosis of Bovine herpesvirus 1 (BHV-1) abortion had been made in all of these cases through multiple testing modalities. Brain tissue from 8 of the 12 fetuses was immunohistochemically stained with a monoclonal antibody specific to BHV-1, and, in 5 fetuses, there was positive intralesional staining of neurons, glial cells, and endothelial cells. This preliminary data suggested that herpesviral infection of brain tissue led to the described neurologic lesions. BHV-1 was then amplified from brain tissue in all 12 of the fetuses and was confirmed by partial sequencing of the thymidine kinase and glycoprotein C genes. To the authors' knowledge, neurologic lesions have not previously been described in BHV-1-infected fetuses, nor has BHV-1 previously been identified in bovine fetal brain tissue. The neurologic histopathology attributed to BHV-1 infection in these cases overlaps with the neurologic lesions produced by Neospora caninum, a common etiologic agent of bovine abortion. Therefore, when bovine fetal neurologic lesions are found, both etiologies should be considered and then distinguished by using additional diagnostic tools.

AB - Brain tissue from 12 aborted bovine fetuses submitted to the Wisconsin Veterinary Diagnostic Laboratory revealed histologic lesions that consisted of glial nodules and variable degrees of mononuclear inflammation, microhemorrhage, neuronal necrosis, and cerebral cortical cavitation. A diagnosis of Bovine herpesvirus 1 (BHV-1) abortion had been made in all of these cases through multiple testing modalities. Brain tissue from 8 of the 12 fetuses was immunohistochemically stained with a monoclonal antibody specific to BHV-1, and, in 5 fetuses, there was positive intralesional staining of neurons, glial cells, and endothelial cells. This preliminary data suggested that herpesviral infection of brain tissue led to the described neurologic lesions. BHV-1 was then amplified from brain tissue in all 12 of the fetuses and was confirmed by partial sequencing of the thymidine kinase and glycoprotein C genes. To the authors' knowledge, neurologic lesions have not previously been described in BHV-1-infected fetuses, nor has BHV-1 previously been identified in bovine fetal brain tissue. The neurologic histopathology attributed to BHV-1 infection in these cases overlaps with the neurologic lesions produced by Neospora caninum, a common etiologic agent of bovine abortion. Therefore, when bovine fetal neurologic lesions are found, both etiologies should be considered and then distinguished by using additional diagnostic tools.

KW - Bovine herpesvirus 1

KW - Bovines

KW - Encephalitis

KW - Fetus

KW - Herpesvirus

KW - Neospora

UR - http://www.scopus.com/inward/record.url?scp=54549114417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54549114417&partnerID=8YFLogxK

U2 - 10.1177/104063870802000306

DO - 10.1177/104063870802000306

M3 - Article

C2 - 18460615

AN - SCOPUS:54549114417

VL - 20

SP - 297

EP - 303

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

IS - 3

ER -