Abstract
Brain tissue from 12 aborted bovine fetuses submitted to the Wisconsin Veterinary Diagnostic Laboratory revealed histologic lesions that consisted of glial nodules and variable degrees of mononuclear inflammation, microhemorrhage, neuronal necrosis, and cerebral cortical cavitation. A diagnosis of Bovine herpesvirus 1 (BHV-1) abortion had been made in all of these cases through multiple testing modalities. Brain tissue from 8 of the 12 fetuses was immunohistochemically stained with a monoclonal antibody specific to BHV-1, and, in 5 fetuses, there was positive intralesional staining of neurons, glial cells, and endothelial cells. This preliminary data suggested that herpesviral infection of brain tissue led to the described neurologic lesions. BHV-1 was then amplified from brain tissue in all 12 of the fetuses and was confirmed by partial sequencing of the thymidine kinase and glycoprotein C genes. To the authors' knowledge, neurologic lesions have not previously been described in BHV-1-infected fetuses, nor has BHV-1 previously been identified in bovine fetal brain tissue. The neurologic histopathology attributed to BHV-1 infection in these cases overlaps with the neurologic lesions produced by Neospora caninum, a common etiologic agent of bovine abortion. Therefore, when bovine fetal neurologic lesions are found, both etiologies should be considered and then distinguished by using additional diagnostic tools.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 297-303 |
| Number of pages | 7 |
| Journal | Journal of Veterinary Diagnostic Investigation |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 1 2008 |
| Externally published | Yes |
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Keywords
- Bovine herpesvirus 1
- Bovines
- Encephalitis
- Fetus
- Herpesvirus
- Neospora
ASJC Scopus subject areas
- veterinary(all)
Cite this
Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection. / Brower, Alexandra; Homb, Kelly M.; Bochsler, Philip; Porter, Robert; Woods, Karen; Ubl, Sue; Krueger, David; Cigel, Francine; Kurth, Kathy L.
In: Journal of Veterinary Diagnostic Investigation, Vol. 20, No. 3, 01.05.2008, p. 297-303.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection
AU - Brower, Alexandra
AU - Homb, Kelly M.
AU - Bochsler, Philip
AU - Porter, Robert
AU - Woods, Karen
AU - Ubl, Sue
AU - Krueger, David
AU - Cigel, Francine
AU - Kurth, Kathy L.
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Brain tissue from 12 aborted bovine fetuses submitted to the Wisconsin Veterinary Diagnostic Laboratory revealed histologic lesions that consisted of glial nodules and variable degrees of mononuclear inflammation, microhemorrhage, neuronal necrosis, and cerebral cortical cavitation. A diagnosis of Bovine herpesvirus 1 (BHV-1) abortion had been made in all of these cases through multiple testing modalities. Brain tissue from 8 of the 12 fetuses was immunohistochemically stained with a monoclonal antibody specific to BHV-1, and, in 5 fetuses, there was positive intralesional staining of neurons, glial cells, and endothelial cells. This preliminary data suggested that herpesviral infection of brain tissue led to the described neurologic lesions. BHV-1 was then amplified from brain tissue in all 12 of the fetuses and was confirmed by partial sequencing of the thymidine kinase and glycoprotein C genes. To the authors' knowledge, neurologic lesions have not previously been described in BHV-1-infected fetuses, nor has BHV-1 previously been identified in bovine fetal brain tissue. The neurologic histopathology attributed to BHV-1 infection in these cases overlaps with the neurologic lesions produced by Neospora caninum, a common etiologic agent of bovine abortion. Therefore, when bovine fetal neurologic lesions are found, both etiologies should be considered and then distinguished by using additional diagnostic tools.
AB - Brain tissue from 12 aborted bovine fetuses submitted to the Wisconsin Veterinary Diagnostic Laboratory revealed histologic lesions that consisted of glial nodules and variable degrees of mononuclear inflammation, microhemorrhage, neuronal necrosis, and cerebral cortical cavitation. A diagnosis of Bovine herpesvirus 1 (BHV-1) abortion had been made in all of these cases through multiple testing modalities. Brain tissue from 8 of the 12 fetuses was immunohistochemically stained with a monoclonal antibody specific to BHV-1, and, in 5 fetuses, there was positive intralesional staining of neurons, glial cells, and endothelial cells. This preliminary data suggested that herpesviral infection of brain tissue led to the described neurologic lesions. BHV-1 was then amplified from brain tissue in all 12 of the fetuses and was confirmed by partial sequencing of the thymidine kinase and glycoprotein C genes. To the authors' knowledge, neurologic lesions have not previously been described in BHV-1-infected fetuses, nor has BHV-1 previously been identified in bovine fetal brain tissue. The neurologic histopathology attributed to BHV-1 infection in these cases overlaps with the neurologic lesions produced by Neospora caninum, a common etiologic agent of bovine abortion. Therefore, when bovine fetal neurologic lesions are found, both etiologies should be considered and then distinguished by using additional diagnostic tools.
KW - Bovine herpesvirus 1
KW - Bovines
KW - Encephalitis
KW - Fetus
KW - Herpesvirus
KW - Neospora
UR - http://www.scopus.com/inward/record.url?scp=54549114417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54549114417&partnerID=8YFLogxK
U2 - 10.1177/104063870802000306
DO - 10.1177/104063870802000306
M3 - Article
C2 - 18460615
AN - SCOPUS:54549114417
VL - 20
SP - 297
EP - 303
JO - Journal of Veterinary Diagnostic Investigation
JF - Journal of Veterinary Diagnostic Investigation
SN - 1040-6387
IS - 3
ER -