Enantioselective intramolecular C-H insertion reactions of donor-donor metal carbenoids

Cristian Soldi, Kellan N. Lamb, Richard A. Squitieri, Marcos González-López, Michael J. Di Maso, Jared T. Shaw

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

The first asymmetric insertion reactions of donor-donor carbenoids, i.e., those with no pendant electron-withdrawing groups, are reported. This process enables the synthesis of densely substituted benzodihydrofurans with high levels of enantio- and diastereoselectivity. Preliminary results show similar efficiency in the preparation of indanes. This new method is used in the first enantioselective synthesis of an oligoresveratrol natural product (E-δ-viniferin).

Original languageEnglish (US)
Pages (from-to)15142-15145
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number43
DOIs
StatePublished - Oct 29 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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