Enantioselective gas-phase ion-molecule reactions in a quadrupole ion trap

Gabriela Grigorean; Scott Gronert; Carlito B Lebrilla

doi:10.1016/S1387-3806(02)00558-4

Enantioselective gas-phase ion-molecule reactions in a quadrupole ion trap

Gabriela Grigorean, Scott Gronert, Carlito B Lebrilla

Biochemistry and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Ion trap mass spectrometry (ITMS) was employed to study chiral guest-exchange reactions in gas-phase complexes of amino acids and β-cyclodextrin. Enantioselectivity was obtained with a selected group of amino acids containing alkyl side chains. The selectivity for the amino acids increased with the size of the side chain except for Phe where the selectivity dropped off considerably. The results were consistent with those obtained earlier with Fourier-transform mass spectrometry (FTMS). The two mass analyzers were compared with regard to enantiomeric analysis.

Original language	English (US)
Pages (from-to)	79-87
Number of pages	9
Journal	International Journal of Mass Spectrometry
Volume	219
Issue number	1
DOIs	https://doi.org/10.1016/S1387-3806(02)00558-4
State	Published - Aug 1 2002

Keywords

Cyclodextrin
Enantioselectivity
Ion trap

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Spectroscopy

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title = "Enantioselective gas-phase ion-molecule reactions in a quadrupole ion trap",

abstract = "Ion trap mass spectrometry (ITMS) was employed to study chiral guest-exchange reactions in gas-phase complexes of amino acids and β-cyclodextrin. Enantioselectivity was obtained with a selected group of amino acids containing alkyl side chains. The selectivity for the amino acids increased with the size of the side chain except for Phe where the selectivity dropped off considerably. The results were consistent with those obtained earlier with Fourier-transform mass spectrometry (FTMS). The two mass analyzers were compared with regard to enantiomeric analysis.",

keywords = "Cyclodextrin, Enantioselectivity, Ion trap",

author = "Gabriela Grigorean and Scott Gronert and Lebrilla, {Carlito B}",

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T1 - Enantioselective gas-phase ion-molecule reactions in a quadrupole ion trap

AU - Grigorean, Gabriela

AU - Gronert, Scott

AU - Lebrilla, Carlito B

PY - 2002/8/1

Y1 - 2002/8/1

N2 - Ion trap mass spectrometry (ITMS) was employed to study chiral guest-exchange reactions in gas-phase complexes of amino acids and β-cyclodextrin. Enantioselectivity was obtained with a selected group of amino acids containing alkyl side chains. The selectivity for the amino acids increased with the size of the side chain except for Phe where the selectivity dropped off considerably. The results were consistent with those obtained earlier with Fourier-transform mass spectrometry (FTMS). The two mass analyzers were compared with regard to enantiomeric analysis.

AB - Ion trap mass spectrometry (ITMS) was employed to study chiral guest-exchange reactions in gas-phase complexes of amino acids and β-cyclodextrin. Enantioselectivity was obtained with a selected group of amino acids containing alkyl side chains. The selectivity for the amino acids increased with the size of the side chain except for Phe where the selectivity dropped off considerably. The results were consistent with those obtained earlier with Fourier-transform mass spectrometry (FTMS). The two mass analyzers were compared with regard to enantiomeric analysis.

KW - Cyclodextrin

KW - Enantioselectivity

KW - Ion trap

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VL - 219

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EP - 87

JO - International Journal of Mass Spectrometry

JF - International Journal of Mass Spectrometry

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