Enantioselective gas-phase ion-molecule reactions in a quadrupole ion trap

Gabriela Grigorean, Scott Gronert, Carlito B Lebrilla

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Ion trap mass spectrometry (ITMS) was employed to study chiral guest-exchange reactions in gas-phase complexes of amino acids and β-cyclodextrin. Enantioselectivity was obtained with a selected group of amino acids containing alkyl side chains. The selectivity for the amino acids increased with the size of the side chain except for Phe where the selectivity dropped off considerably. The results were consistent with those obtained earlier with Fourier-transform mass spectrometry (FTMS). The two mass analyzers were compared with regard to enantiomeric analysis.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalInternational Journal of Mass Spectrometry
Volume219
Issue number1
DOIs
StatePublished - Aug 1 2002

Keywords

  • Cyclodextrin
  • Enantioselectivity
  • Ion trap

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Spectroscopy

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