Enantiomeric analysis of pharmaceutical compounds by Ion/molecule reactions

G. Grigorean, Carlito B Lebrilla

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Protonated complexes involving cyclodextrin hosts and guest compounds that are pharmacologically important are produced in the gas phase and reacted with a gaseous amine. The guest is exchanged to produce a new protonated complex with the amine. The reaction is enantioselective and is used to develop a method for determining enantiomeric excess using only mass spectrometry. The pharmaceutical compounds include DOPA, amphetamine, ephedrine, and penicillamine. The presence of more than one reacting species is observed with DOPA and penicillamine. Molecular dynamics calculations are used to understand the nature of the interactions and the possible source of the variations in the reactivities.

Original languageEnglish (US)
Pages (from-to)1684-1691
Number of pages8
JournalAnalytical Chemistry
Volume73
Issue number8
DOIs
StatePublished - Apr 15 2001

ASJC Scopus subject areas

  • Analytical Chemistry

Fingerprint Dive into the research topics of 'Enantiomeric analysis of pharmaceutical compounds by Ion/molecule reactions'. Together they form a unique fingerprint.

Cite this