Emerging Therapies for Acne Vulgaris

Megha K. Trivedi, Suzana S. Bosanac, Raja K Sivamani, Larissa N Larsen

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

As we gain a greater understanding of acne pathogenesis, both new agents as well as new uses for established drugs are being considered for the treatment of acne vulgaris. Multiple clinical trials assessing new formulations or combinations of established acne treatments have been conducted, and novel uses of antimicrobials such as modified diallyl disulfide oxide and nitric oxide are being assessed in clinical trials. There are also a multitude of new therapies currently being studied that target the inflammatory cascade of acne pathogenesis, including sebosuppressive and anti-inflammatory phytochemicals, and small molecule inhibitors targeting sebaceous glands and enzymes, among others. Laser and light therapy is also being modified for the treatment of acne through combination methods with metal nanoshells and vacuum assistance. Probiotics have gained popularity in medicine as greater knowledge of the microbiome and its effects on multiple organ systems is being elucidated. Studies describing the positive effects of certain ammonia-oxidizing bacterial strains in the regulation of the skin’s inflammatory response are ongoing. Therapies for acne are constantly evolving and current gold-standard acne therapy may be supplemented with novel treatment modalities in the near future.

Original languageEnglish (US)
Pages (from-to)505-516
Number of pages12
JournalAmerican Journal of Clinical Dermatology
Volume19
Issue number4
DOIs
StatePublished - Aug 1 2018

Fingerprint

Acne Vulgaris
Therapeutics
Nanoshells
Clinical Trials
Sebaceous Glands
Phototherapy
Microbiota
Probiotics
Phytochemicals
Laser Therapy
Vacuum
Ammonia
Gold
Nitric Oxide
Anti-Inflammatory Agents
Medicine
Skin
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Dermatology

Cite this

Emerging Therapies for Acne Vulgaris. / Trivedi, Megha K.; Bosanac, Suzana S.; Sivamani, Raja K; Larsen, Larissa N.

In: American Journal of Clinical Dermatology, Vol. 19, No. 4, 01.08.2018, p. 505-516.

Research output: Contribution to journalReview article

Trivedi, Megha K. ; Bosanac, Suzana S. ; Sivamani, Raja K ; Larsen, Larissa N. / Emerging Therapies for Acne Vulgaris. In: American Journal of Clinical Dermatology. 2018 ; Vol. 19, No. 4. pp. 505-516.
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