Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals

T. Michael Nork, Carol A. Rasmussen, Brian J. Christian, Mary Ann Croft, Christopher J. Murphy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent decades have seen a dramatic increase in ocular imaging technologies—both for the anterior and posterior segments. This has been largely the result of increased computer processing power as applied to hardware control and data analysis. For example, the theoretical basis for ocular coherence tomography (OCT) was developed by Michelson in the nineteenth century, but only recently, thanks to computers, lasers, and electronic control circuitry, has it become a practical tool in the clinical and for toxicological studies. In the aggregate, the use of advanced imaging may be expected to improve the drug development process by providing high-quality and clinically relevant data, which enable earlier and more informed decision making at the preclinical stage of drug development. This accompanied with gains in efficient use of resources can reduce the overall time and cost required to bring a new drug to market. In this chapter, we review the capabilities and limitations of advanced ocular imaging and diagnostic tools that are commercially available and appropriate for inclusion in the design and execution of preclinical programs in ocular drug development.

Original languageEnglish (US)
Title of host publicationMolecular and Integrative Toxicology
PublisherSpringer Science+Business Media B.V.
Pages53-121
Number of pages69
DOIs
StatePublished - 2013

Publication series

NameMolecular and Integrative Toxicology
ISSN (Print)2168-4219
ISSN (Electronic)2168-4235

Keywords

  • Anterior Chamber Depth
  • Central Corneal Thickness
  • Optical Coherence Tomography
  • Retinal Nerve Fiber Layer
  • Retinal Nerve Fiber Layer Thickness

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pharmacology (medical)
  • Drug Discovery
  • Toxicology

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