Emerging Cancer Therapeutic Targets in Protein Homeostasis

Prabhakar Bastola, Derek B. Oien, Megan Cooley, Jeremy Chien

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Genomic aberrations inside malignant cells through copy number alterations, aneuploidy, and mutations can exacerbate misfolded and unfolded protein burden resulting in increased proteotoxic stress. Increased proteotoxic stress can be deleterious to malignant cells; therefore, these cells rely heavily on the protein quality control mechanisms for survival and proliferation. Components of the protein quality control, such as the unfolded protein response, heat shock proteins, autophagy, and the ubiquitin proteasome system, orchestrate a cascade of downstream events that allow the mitigation of the proteotoxic stress. This dependency makes components of the protein quality control mechanisms attractive targets in cancer therapeutics. In this review, we explore the components of the protein homeostasis especially focusing on the emerging cancer therapeutic agents/targets that are being actively pursued actively.

Original languageEnglish (US)
Article number94
JournalAAPS Journal
Volume20
Issue number6
DOIs
StatePublished - Nov 1 2018
Externally publishedYes

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Keywords

  • autophagy
  • heat shock proteins
  • protein quality control
  • ubiquitin proteasome system
  • unfolded protein response

ASJC Scopus subject areas

  • Pharmaceutical Science

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