Emerging Cancer Therapeutic Targets in Protein Homeostasis

Prabhakar Bastola, Derek B. Oien, Megan Cooley, Jeremy Chien

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Genomic aberrations inside malignant cells through copy number alterations, aneuploidy, and mutations can exacerbate misfolded and unfolded protein burden resulting in increased proteotoxic stress. Increased proteotoxic stress can be deleterious to malignant cells; therefore, these cells rely heavily on the protein quality control mechanisms for survival and proliferation. Components of the protein quality control, such as the unfolded protein response, heat shock proteins, autophagy, and the ubiquitin proteasome system, orchestrate a cascade of downstream events that allow the mitigation of the proteotoxic stress. This dependency makes components of the protein quality control mechanisms attractive targets in cancer therapeutics. In this review, we explore the components of the protein homeostasis especially focusing on the emerging cancer therapeutic agents/targets that are being actively pursued actively.

Original languageEnglish (US)
Article number94
JournalAAPS Journal
Volume20
Issue number6
DOIs
StatePublished - Nov 1 2018
Externally publishedYes

Fingerprint

Homeostasis
Quality Control
Neoplasms
Proteins
Unfolded Protein Response
Protein Unfolding
Autophagy
Aneuploidy
Proteasome Endopeptidase Complex
Therapeutics
Ubiquitin
Heat-Shock Proteins
Mutation

Keywords

  • autophagy
  • heat shock proteins
  • protein quality control
  • ubiquitin proteasome system
  • unfolded protein response

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Emerging Cancer Therapeutic Targets in Protein Homeostasis. / Bastola, Prabhakar; Oien, Derek B.; Cooley, Megan; Chien, Jeremy.

In: AAPS Journal, Vol. 20, No. 6, 94, 01.11.2018.

Research output: Contribution to journalReview article

Bastola, Prabhakar ; Oien, Derek B. ; Cooley, Megan ; Chien, Jeremy. / Emerging Cancer Therapeutic Targets in Protein Homeostasis. In: AAPS Journal. 2018 ; Vol. 20, No. 6.
@article{15dba092f11e40bdbd98cf5195452d88,
title = "Emerging Cancer Therapeutic Targets in Protein Homeostasis",
abstract = "Genomic aberrations inside malignant cells through copy number alterations, aneuploidy, and mutations can exacerbate misfolded and unfolded protein burden resulting in increased proteotoxic stress. Increased proteotoxic stress can be deleterious to malignant cells; therefore, these cells rely heavily on the protein quality control mechanisms for survival and proliferation. Components of the protein quality control, such as the unfolded protein response, heat shock proteins, autophagy, and the ubiquitin proteasome system, orchestrate a cascade of downstream events that allow the mitigation of the proteotoxic stress. This dependency makes components of the protein quality control mechanisms attractive targets in cancer therapeutics. In this review, we explore the components of the protein homeostasis especially focusing on the emerging cancer therapeutic agents/targets that are being actively pursued actively.",
keywords = "autophagy, heat shock proteins, protein quality control, ubiquitin proteasome system, unfolded protein response",
author = "Prabhakar Bastola and Oien, {Derek B.} and Megan Cooley and Jeremy Chien",
year = "2018",
month = "11",
day = "1",
doi = "10.1208/s12248-018-0254-1",
language = "English (US)",
volume = "20",
journal = "AAPS Journal",
issn = "1550-7416",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Emerging Cancer Therapeutic Targets in Protein Homeostasis

AU - Bastola, Prabhakar

AU - Oien, Derek B.

AU - Cooley, Megan

AU - Chien, Jeremy

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Genomic aberrations inside malignant cells through copy number alterations, aneuploidy, and mutations can exacerbate misfolded and unfolded protein burden resulting in increased proteotoxic stress. Increased proteotoxic stress can be deleterious to malignant cells; therefore, these cells rely heavily on the protein quality control mechanisms for survival and proliferation. Components of the protein quality control, such as the unfolded protein response, heat shock proteins, autophagy, and the ubiquitin proteasome system, orchestrate a cascade of downstream events that allow the mitigation of the proteotoxic stress. This dependency makes components of the protein quality control mechanisms attractive targets in cancer therapeutics. In this review, we explore the components of the protein homeostasis especially focusing on the emerging cancer therapeutic agents/targets that are being actively pursued actively.

AB - Genomic aberrations inside malignant cells through copy number alterations, aneuploidy, and mutations can exacerbate misfolded and unfolded protein burden resulting in increased proteotoxic stress. Increased proteotoxic stress can be deleterious to malignant cells; therefore, these cells rely heavily on the protein quality control mechanisms for survival and proliferation. Components of the protein quality control, such as the unfolded protein response, heat shock proteins, autophagy, and the ubiquitin proteasome system, orchestrate a cascade of downstream events that allow the mitigation of the proteotoxic stress. This dependency makes components of the protein quality control mechanisms attractive targets in cancer therapeutics. In this review, we explore the components of the protein homeostasis especially focusing on the emerging cancer therapeutic agents/targets that are being actively pursued actively.

KW - autophagy

KW - heat shock proteins

KW - protein quality control

KW - ubiquitin proteasome system

KW - unfolded protein response

UR - http://www.scopus.com/inward/record.url?scp=85052301449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052301449&partnerID=8YFLogxK

U2 - 10.1208/s12248-018-0254-1

DO - 10.1208/s12248-018-0254-1

M3 - Review article

C2 - 30151644

AN - SCOPUS:85052301449

VL - 20

JO - AAPS Journal

JF - AAPS Journal

SN - 1550-7416

IS - 6

M1 - 94

ER -