Embolisation therapy in the midgut carcinoid syndrome: Just tumour ischaemia??

Bo Wängberg, Kjell Geterud, Ola Nilsson, Svante Jansson, Annica Dahlström, Ulf Tylen, Håkan Ahlman

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Forty-eight patients with midgut carcinoid tumours and disseminated disease were treated at our unit 1986-1991. All patients underwent primary surgery with optimal tumour reduction. Twenty-seven patients with bilobar liver metastases had subsequent embolisations of the hepatic arteries to further reduce the functional tumour mass and were thereafter treated with a low dose of octreotide. The response to this treatment was evaluated by CT at 3 months postembolisation. The patients could then be divided into 13 responders (no visible hepatic tumours or more than 50% reduction, group I) and 14 non-responders (less than 50 reduction or progression, group II). When these patients were studied biochemically and in terms of prognosis, the reduction of 5-HIAA levels postembolisation was much more pronounced in group I (80 ± 3% then in group II (28 ± 12% The biochemical and radiological responses were long-lasting in group I, none of the patients needed further ischaemic treatment. of specific interest were 3 patients with bilobar disease, who after selective unilobar embolisation normalised their 5-HIAA levels and had bilateral tumour regression. These findings indicate involvement of systemic effects in addition to tumour ischaemia alone. The initial biochemical response with marked decrease of 5-HIAA levels in combination with tumour regression may thus serve as an indicator of good prognosis.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalActa Oncologica
Volume32
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

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    Wängberg, B., Geterud, K., Nilsson, O., Jansson, S., Dahlström, A., Tylen, U., & Ahlman, H. (1993). Embolisation therapy in the midgut carcinoid syndrome: Just tumour ischaemia?? Acta Oncologica, 32(2), 251-256. https://doi.org/10.3109/02841869309083921