Elucidation of the receptor-bound conformation of the enkephalins

Fredric A Gorin, T. M. Balasubramanian, C. D. Barry, G. R. Marshall

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Scopus citations

Abstract

The biologically relevant conformers of enkephalin predicted by solid state, solution state, and theoretical energy studies have been compared with the published structure-activity data on these compounds. No confirmational technique proposes a model consistent with all the pharmacological data; the shortcomings of each approach are evaluated. An alternative approach, which correlates the structure-activity data of opiate compounds with that of the enkephalins, is described and shown to produce a model consistent with the available structure-activity data.

Original languageEnglish (US)
Title of host publicationJournal of Supramolecular and Cellular Biochemistry
Pages27-39
Number of pages13
Volume9
Edition1
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Gorin, F. A., Balasubramanian, T. M., Barry, C. D., & Marshall, G. R. (1979). Elucidation of the receptor-bound conformation of the enkephalins. In Journal of Supramolecular and Cellular Biochemistry (1 ed., Vol. 9, pp. 27-39)