Eliprodil prevents expression of the 70 kDa heat shock protein in MK801-Injured neurones

Shu Wang, Qiner Yang, Claus J. Moller, Frank R Sharp, Kenneth G. Haglid

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The present study examined whether eliprodil (SL 82.0715), an N-methyl-D-aspartate (NMDA) receptor antagonist acting on the polyamine sites induced expression of the 70 kDa heat shock protein (HSP70) in the rat brain. Whereas the NMDA channel blocker MK801 consistently induced HSP70 in posterior cingulate and retrosplenial cortices, eliprodil had no such effects even at the highest dose (50 mg/kg, intraperitoneally), supporting the idea that injury to the cerebro-cortical neurones by NMDA receptor antagonists is probably related to specific sites of the receptor. Furthermore, eliprodil, given immediately after injection of MK801, blocked the effects of MK801 on HSP70. The result is discussed in terms of high affinity of eliprodil for the σ receptor.

Original languageEnglish (US)
Pages (from-to)166-168
Number of pages3
JournalPharmacology and Toxicology
Volume79
Issue number3
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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