Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses

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Abstract

Cetirizine is an antihistamine used in performance horses for the treatment of hypersensitivity reactions and as such a withdrawal time is necessary prior to competition. The objective of the current study was to describe the disposition and elimination of cetirizine following oral administration in order to provide additional serum concentration data upon which appropriate regulatory recommendations can be established. Nine exercised thoroughbred horses were administered 0.4 mg/kg of cetirizine orally BID for a total of five doses. Blood samples were collected immediately prior to drug administration and at various times postadministration. Serum cetirizine concentrations were determined and selected pharmacokinetic parameters determined. The serum elimination half-life was 5.83 ± 0.841 h. Average serum cetirizine concentrations were still above the LOQ of the assay (0.05 ng/mL) at 48 h (final sample collected) postadministration of the final dose.

Original languageEnglish (US)
Pages (from-to)522-524
Number of pages3
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume39
Issue number5
DOIs
StatePublished - 2016

Fingerprint

Cetirizine
blood serum
Horses
horses
dosage
Serum
antihistamines
hypersensitivity
oral administration
pharmacokinetics
Histamine Antagonists
half life
Oral Administration
Half-Life
Hypersensitivity
sampling
drugs
Pharmacokinetics
blood
assays

ASJC Scopus subject areas

  • veterinary(all)
  • Pharmacology

Cite this

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title = "Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses",
abstract = "Cetirizine is an antihistamine used in performance horses for the treatment of hypersensitivity reactions and as such a withdrawal time is necessary prior to competition. The objective of the current study was to describe the disposition and elimination of cetirizine following oral administration in order to provide additional serum concentration data upon which appropriate regulatory recommendations can be established. Nine exercised thoroughbred horses were administered 0.4 mg/kg of cetirizine orally BID for a total of five doses. Blood samples were collected immediately prior to drug administration and at various times postadministration. Serum cetirizine concentrations were determined and selected pharmacokinetic parameters determined. The serum elimination half-life was 5.83 ± 0.841 h. Average serum cetirizine concentrations were still above the LOQ of the assay (0.05 ng/mL) at 48 h (final sample collected) postadministration of the final dose.",
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