Elimination kinetics of ethanol in a 5-week-old infant and a literature review of infant ethanol pharmacokinetics

Jonathan B Ford, Mac T. Wayment, Timothy E Albertson, Kelly Owen, Joshua B. Radke, Mark E Sutter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Primary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the P450 enzymes CYP2E1 and CYP1A2 and the enzyme catalase exist. These enzymes have distinct developmental stages. Elimination kinetics of ethanol in the infant is limited. We report the elimination kinetics of ethanol in a 5-week-old African-American male who had a serum ethanol level of 270 mg/dL on admission. A previously healthy 5-week-old African-American male was brought to the ED with a decreased level of consciousness. His initial blood ethanol level was 270 mg/dL. Serial blood ethanol levels were obtained. The elimination rate of ethanol was calculated to be in a range from 17.1 to 21.2 mg/dL/hr and appeared to follow zero-order elimination kinetics with a R2=0.9787. Elimination kinetics for ethanol in the young infant has been reported in only four previously published reports. After reviewing these reports, there appears to be variability in the elimination rates of ethanol in infants. Very young infants may not eliminate ethanol as quickly as previously described. Given that there are different stages of enzyme development in children, caution should be used when generalizing the elimination kinetics in young infants and children.

Original languageEnglish (US)
Article number250716
JournalCase Reports in Medicine
Volume2013
DOIs
StatePublished - 2013

Fingerprint

Ethanol
Pharmacokinetics
African Americans
Enzymes
Cytochrome P-450 CYP2E1
Cytochrome P-450 CYP1A2
Alcohol Dehydrogenase
Child Development
Metabolic Networks and Pathways
Consciousness
Catalase
Cytochrome P-450 Enzyme System
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Elimination kinetics of ethanol in a 5-week-old infant and a literature review of infant ethanol pharmacokinetics. / Ford, Jonathan B; Wayment, Mac T.; Albertson, Timothy E; Owen, Kelly; Radke, Joshua B.; Sutter, Mark E.

In: Case Reports in Medicine, Vol. 2013, 250716, 2013.

Research output: Contribution to journalArticle

@article{b142b8d08a984538a9c24e94a30fc7d0,
title = "Elimination kinetics of ethanol in a 5-week-old infant and a literature review of infant ethanol pharmacokinetics",
abstract = "Primary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the P450 enzymes CYP2E1 and CYP1A2 and the enzyme catalase exist. These enzymes have distinct developmental stages. Elimination kinetics of ethanol in the infant is limited. We report the elimination kinetics of ethanol in a 5-week-old African-American male who had a serum ethanol level of 270 mg/dL on admission. A previously healthy 5-week-old African-American male was brought to the ED with a decreased level of consciousness. His initial blood ethanol level was 270 mg/dL. Serial blood ethanol levels were obtained. The elimination rate of ethanol was calculated to be in a range from 17.1 to 21.2 mg/dL/hr and appeared to follow zero-order elimination kinetics with a R2=0.9787. Elimination kinetics for ethanol in the young infant has been reported in only four previously published reports. After reviewing these reports, there appears to be variability in the elimination rates of ethanol in infants. Very young infants may not eliminate ethanol as quickly as previously described. Given that there are different stages of enzyme development in children, caution should be used when generalizing the elimination kinetics in young infants and children.",
author = "Ford, {Jonathan B} and Wayment, {Mac T.} and Albertson, {Timothy E} and Kelly Owen and Radke, {Joshua B.} and Sutter, {Mark E}",
year = "2013",
doi = "10.1155/2013/250716",
language = "English (US)",
volume = "2013",
journal = "Case Reports in Medicine",
issn = "1687-9627",
publisher = "Hindawi Limited",

}

TY - JOUR

T1 - Elimination kinetics of ethanol in a 5-week-old infant and a literature review of infant ethanol pharmacokinetics

AU - Ford, Jonathan B

AU - Wayment, Mac T.

AU - Albertson, Timothy E

AU - Owen, Kelly

AU - Radke, Joshua B.

AU - Sutter, Mark E

PY - 2013

Y1 - 2013

N2 - Primary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the P450 enzymes CYP2E1 and CYP1A2 and the enzyme catalase exist. These enzymes have distinct developmental stages. Elimination kinetics of ethanol in the infant is limited. We report the elimination kinetics of ethanol in a 5-week-old African-American male who had a serum ethanol level of 270 mg/dL on admission. A previously healthy 5-week-old African-American male was brought to the ED with a decreased level of consciousness. His initial blood ethanol level was 270 mg/dL. Serial blood ethanol levels were obtained. The elimination rate of ethanol was calculated to be in a range from 17.1 to 21.2 mg/dL/hr and appeared to follow zero-order elimination kinetics with a R2=0.9787. Elimination kinetics for ethanol in the young infant has been reported in only four previously published reports. After reviewing these reports, there appears to be variability in the elimination rates of ethanol in infants. Very young infants may not eliminate ethanol as quickly as previously described. Given that there are different stages of enzyme development in children, caution should be used when generalizing the elimination kinetics in young infants and children.

AB - Primary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the P450 enzymes CYP2E1 and CYP1A2 and the enzyme catalase exist. These enzymes have distinct developmental stages. Elimination kinetics of ethanol in the infant is limited. We report the elimination kinetics of ethanol in a 5-week-old African-American male who had a serum ethanol level of 270 mg/dL on admission. A previously healthy 5-week-old African-American male was brought to the ED with a decreased level of consciousness. His initial blood ethanol level was 270 mg/dL. Serial blood ethanol levels were obtained. The elimination rate of ethanol was calculated to be in a range from 17.1 to 21.2 mg/dL/hr and appeared to follow zero-order elimination kinetics with a R2=0.9787. Elimination kinetics for ethanol in the young infant has been reported in only four previously published reports. After reviewing these reports, there appears to be variability in the elimination rates of ethanol in infants. Very young infants may not eliminate ethanol as quickly as previously described. Given that there are different stages of enzyme development in children, caution should be used when generalizing the elimination kinetics in young infants and children.

UR - http://www.scopus.com/inward/record.url?scp=84908274080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908274080&partnerID=8YFLogxK

U2 - 10.1155/2013/250716

DO - 10.1155/2013/250716

M3 - Article

AN - SCOPUS:84908274080

VL - 2013

JO - Case Reports in Medicine

JF - Case Reports in Medicine

SN - 1687-9627

M1 - 250716

ER -