Elevation of plasma cholecystokinin concentration following a meal is increased by gonadectomy in male cats

R. C. Backus, M. L. Kanchuk, Quinton Rogers

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An overweight or obese body condition commonly develops after gonadectomy (GX) in domestic cats. The cause appears to be a rapid, quantal (approximately 12%), increase in food intake that is sustained and probably mediated by withdrawal of gonadal hormone. Recently, an interaction of gonadal hormone and cholecystokinin (CCK) effectiveness has been suggested. A reduction in the satiating potency of intestinal CCK was presently hypothesized to contribute to the disturbance of food intake control caused by GX in domestic cats. Pre- and post-prandial intestinal CCK secretion as indicated by plasma CCK concentrations were determined in 16 adult male cats (5.1 ± 0.1 kg) 8 weeks before and 57 weeks after eight of the cats were gonadectomized. During ad libitum intake of a commercial dry, expanded diet, body weight increased from 22% to 28% in gonadectomized cats and was unchanged in intact cats. Baseline CCK concentrations were not different between gonadectomized and intact cats. Amounts of diet ingested during CCK determinations were 15-19% of daily metabolizable energy requirement and were not different between gonadectomized and intact cats. The post-prandial area under the curve (AUC; 0-400 min) CCK concentration increased linearly with meal size (p < 0.01) and was not correlated with body weight. Area under the curve CCK concentration, when normalized for meal size, was 34% greater (p < 0.01) in gonadectomized cats than that in intact cats. The findings indicate GX increases meal-induced intestinal CCK secretion and therefore, do not support the study hypothesis. The findings indicate GX may slow digestion and absorption and attenuate inhibition of food intake by CCK.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalJournal of Animal Physiology and Animal Nutrition
Volume90
Issue number3-4
DOIs
StatePublished - Apr 1 2006

Fingerprint

cholecystokinin
Cholecystokinin
Meals
Cats
cats
Intestinal Secretions
Area Under Curve
Gonadal Hormones
portion size
food intake
Eating
Body Weight
hormones
gonadectomy
secretion
Diet
body weight
energy requirements
metabolizable energy
diet

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology

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Elevation of plasma cholecystokinin concentration following a meal is increased by gonadectomy in male cats. / Backus, R. C.; Kanchuk, M. L.; Rogers, Quinton.

In: Journal of Animal Physiology and Animal Nutrition, Vol. 90, No. 3-4, 01.04.2006, p. 152-158.

Research output: Contribution to journalArticle

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abstract = "An overweight or obese body condition commonly develops after gonadectomy (GX) in domestic cats. The cause appears to be a rapid, quantal (approximately 12{\%}), increase in food intake that is sustained and probably mediated by withdrawal of gonadal hormone. Recently, an interaction of gonadal hormone and cholecystokinin (CCK) effectiveness has been suggested. A reduction in the satiating potency of intestinal CCK was presently hypothesized to contribute to the disturbance of food intake control caused by GX in domestic cats. Pre- and post-prandial intestinal CCK secretion as indicated by plasma CCK concentrations were determined in 16 adult male cats (5.1 ± 0.1 kg) 8 weeks before and 57 weeks after eight of the cats were gonadectomized. During ad libitum intake of a commercial dry, expanded diet, body weight increased from 22{\%} to 28{\%} in gonadectomized cats and was unchanged in intact cats. Baseline CCK concentrations were not different between gonadectomized and intact cats. Amounts of diet ingested during CCK determinations were 15-19{\%} of daily metabolizable energy requirement and were not different between gonadectomized and intact cats. The post-prandial area under the curve (AUC; 0-400 min) CCK concentration increased linearly with meal size (p < 0.01) and was not correlated with body weight. Area under the curve CCK concentration, when normalized for meal size, was 34{\%} greater (p < 0.01) in gonadectomized cats than that in intact cats. The findings indicate GX increases meal-induced intestinal CCK secretion and therefore, do not support the study hypothesis. The findings indicate GX may slow digestion and absorption and attenuate inhibition of food intake by CCK.",
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