Abstract
Exertional rhabdomyolysis is a myopathy of unknown pathophysiology. We measured intracellular resting calcium concentration ([Ca2+]i) by means of Ca2+-selective microelectrodes in intercostal muscle fibers from horses suffering from rhabdomyolysis, and from horses with no evidence of neuromuscular disorder. [Ca2+]i was several-fold higher in muscle fibers from horses suffering from rhabdomyolysis when compared to controls. Treatment of rhabdomyolytic horses with dantrolene, an agent that prevents Ca2+ release from the sarcoplasmic reticulum, reduced [Ca2+]i toward control values, and accelerated the recovery from this myopathy. These results indicate that an acute episode of rhabdomyolysis is associated with elevation in [Ca2+]i in skeletal muscles, and that dantrolene might be of benefit in treating this disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 293-295 |
| Number of pages | 3 |
| Journal | Pflügers Archiv European Journal of Physiology |
| Volume | 430 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1995 |
| Externally published | Yes |
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Keywords
- Calcium
- Dantrolene
- Rhabdomyolysis
- Skeletal Muscle
ASJC Scopus subject areas
- Physiology
Cite this
Elevated myoplasmic calcium in exercise-induced equine rhabdomyolysis. / López, J. R.; Linares, N.; Cordovez, G.; Terzic, A.
In: Pflügers Archiv European Journal of Physiology, Vol. 430, No. 2, 06.1995, p. 293-295.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elevated myoplasmic calcium in exercise-induced equine rhabdomyolysis
AU - López, J. R.
AU - Linares, N.
AU - Cordovez, G.
AU - Terzic, A.
PY - 1995/6
Y1 - 1995/6
N2 - Exertional rhabdomyolysis is a myopathy of unknown pathophysiology. We measured intracellular resting calcium concentration ([Ca2+]i) by means of Ca2+-selective microelectrodes in intercostal muscle fibers from horses suffering from rhabdomyolysis, and from horses with no evidence of neuromuscular disorder. [Ca2+]i was several-fold higher in muscle fibers from horses suffering from rhabdomyolysis when compared to controls. Treatment of rhabdomyolytic horses with dantrolene, an agent that prevents Ca2+ release from the sarcoplasmic reticulum, reduced [Ca2+]i toward control values, and accelerated the recovery from this myopathy. These results indicate that an acute episode of rhabdomyolysis is associated with elevation in [Ca2+]i in skeletal muscles, and that dantrolene might be of benefit in treating this disease.
AB - Exertional rhabdomyolysis is a myopathy of unknown pathophysiology. We measured intracellular resting calcium concentration ([Ca2+]i) by means of Ca2+-selective microelectrodes in intercostal muscle fibers from horses suffering from rhabdomyolysis, and from horses with no evidence of neuromuscular disorder. [Ca2+]i was several-fold higher in muscle fibers from horses suffering from rhabdomyolysis when compared to controls. Treatment of rhabdomyolytic horses with dantrolene, an agent that prevents Ca2+ release from the sarcoplasmic reticulum, reduced [Ca2+]i toward control values, and accelerated the recovery from this myopathy. These results indicate that an acute episode of rhabdomyolysis is associated with elevation in [Ca2+]i in skeletal muscles, and that dantrolene might be of benefit in treating this disease.
KW - Calcium
KW - Dantrolene
KW - Rhabdomyolysis
KW - Skeletal Muscle
UR - http://www.scopus.com/inward/record.url?scp=0029000999&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029000999&partnerID=8YFLogxK
U2 - 10.1007/BF00374661
DO - 10.1007/BF00374661
M3 - Article
C2 - 7675639
AN - SCOPUS:0029000999
VL - 430
SP - 293
EP - 295
JO - Pflugers Archiv European Journal of Physiology
JF - Pflugers Archiv European Journal of Physiology
SN - 0031-6768
IS - 2
ER -