Elevated levels of serum mucin-associated antigen in adult patients with cystic fibrosis

C. B. Robinson, W. R. Martin, J. L. Ratliff, P. V. Holland, Reen Wu, Carroll E Cross

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Previous studies using the CA 19-9 antibody have demonstrated that serum mucin levels in patients with cystic fibrosis (CF) are elevated and that the degree of elevation relates to the age of the patient and possibly to his or her clinical status. However, CA 19-9 only recognizes the mucin-associated blood group sialyl Lea+ antigen, so mucin levels cannot be measured in patients without Lewis antigens. The present study used the 17B1 monoclonal antibody to measure serum mucin levels in normal subjects, and in patients with CF, patients with chronic obstructive pulmonary disease (COPD), and patients with lung transplants. Serum mucin levels were 25 ng/ml (± 1 SEM, n = 8) in normal subjects, 13,853 ng/ml (± 1,281, n = 25) in patients with CF, and 25.5 ng/ml (± 1.9, n = 17) in patients with COPD. Patients with CF who were sialyl Lea-b- also had elevated serum mucin levels (715 ± 152, n = 2). Serum mucin levels of six lung transplant recipients with CF were elevated compared with those in normal subjects (4,621 ± 765 ng/ml), but they were not different from serum mucin levels in six lung transplant recipients without CF (5,307 ± 1,677 ng/ml). Preliminary characterization of the serum mucin antigen showed that: (1) in CF sera, the antigen is polydisperse and smaller than the antigen in normal sera; (2) the mucin antigen is distinct from ABO blood group antigens. Serum mucin levels may be a useful marker to follow a specific patient's response to therapy.

Original languageEnglish (US)
Pages (from-to)385-389
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume148
Issue number2
StatePublished - 1993

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Elevated levels of serum mucin-associated antigen in adult patients with cystic fibrosis'. Together they form a unique fingerprint.

  • Cite this