Electrophysiology of hippocampal CA1 neurons after prenatal ethanol exposure

Scott E. Krahl, Robert F Berman, John H. Hannigan

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


In the present study, we examined the longitudinal effects of prenatal ethanol exposure on the electrophysiological characteristics of CA1 neurons in hippocampal slices. Hippocampal slices were obtained from young (25-32- day old) and adult (63-77-day old) male offspring of rats given one of four treatments during gestation. Three groups of pregnant rats were orally intubated with 0, 4, or 6 g/kg ethanol on gestational days 8-20. Caloric intake for the 0- (nutritional control) and 4-g/kg groups was yoked to that of the 6 g/kg group. A fourth group (untreated control) was not intubated, and was given ad lib access to food. Long-term potentiation and paired-pulse inhibition were unaffected by prenatal ethanol exposure in young and adult rats; however, slices taken from the young 6 g/kg ethanol group displayed a significantly lower maximal CA1 population spike amplitude evoked by Schaffer collateral stimulation as compared to young controls. This difference was not observed in adult animals. These data suggest that some aspects of hippocampal physiology are negatively affected in young rats as a result of prenatal ethanol exposure, but this effect reverses as the animal matures.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
Issue number2
StatePublished - Feb 1999
Externally publishedYes


  • FAS
  • Fetal alcohol syndrome
  • Hippocampus

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neuroscience(all)
  • Toxicology
  • Health(social science)


Dive into the research topics of 'Electrophysiology of hippocampal CA1 neurons after prenatal ethanol exposure'. Together they form a unique fingerprint.

Cite this