Electrophysiological Evidence for Impaired Control of Motor Output in Schizophrenia

Emily S. Kappenman, Steven J. Luck, Ann M. Kring, Tyler A. Lesh, George R Mangun, Tara A Niendam, John D Ragland, Charan Ranganath, Marjorie Solomon Friedman, Tamara Y. Swaab, Cameron S Carter

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Previous research has demonstrated pervasive deficits in response-related processing in people with schizophrenia (PSZ). The present study used behavioral measures and event-related potentials (ERPs) to test the hypothesis that schizophrenia involves specific impairment in the ability to exert control over response-related processing. Twenty-two PSZ and 22 matched control participants completed a choice response task in counterbalanced testing sessions that emphasized only accuracy (the unspeeded condition) or emphasized speed and accuracy equally (the speeded condition). Control participants successfully modulated behavioral and ERP indices of response-related processing under speed pressure, as evidenced by faster and less variable reaction times (RTs) and an earlier onset and increased amplitude lateralized readiness potential (LRP). By contrast, PSZ were unable to improve RT speed or variability or to modulate the LRP under speed pressure, despite showing a decrease in accuracy. Notably, response-related deficits in PSZ emerged only in the speeded condition; behavioral and ERP measures did not differ between groups in the unspeeded condition. Together, these results indicate that impairment in the ability to exert control over response-related processing may underlie response-related deficits in schizophrenia.

Original languageEnglish (US)
Pages (from-to)1891-1899
Number of pages9
JournalCerebral Cortex
Volume26
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Schizophrenia
Evoked Potentials
Contingent Negative Variation
Aptitude
Reaction Time
Pressure
Research

Keywords

  • control
  • ERPs
  • lateralized readiness potential
  • motor
  • response preparation
  • schizophrenia

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

Cite this

Electrophysiological Evidence for Impaired Control of Motor Output in Schizophrenia. / Kappenman, Emily S.; Luck, Steven J.; Kring, Ann M.; Lesh, Tyler A.; Mangun, George R; Niendam, Tara A; Ragland, John D; Ranganath, Charan; Friedman, Marjorie Solomon; Swaab, Tamara Y.; Carter, Cameron S.

In: Cerebral Cortex, Vol. 26, No. 5, 01.05.2016, p. 1891-1899.

Research output: Contribution to journalArticle

Kappenman, Emily S. ; Luck, Steven J. ; Kring, Ann M. ; Lesh, Tyler A. ; Mangun, George R ; Niendam, Tara A ; Ragland, John D ; Ranganath, Charan ; Friedman, Marjorie Solomon ; Swaab, Tamara Y. ; Carter, Cameron S. / Electrophysiological Evidence for Impaired Control of Motor Output in Schizophrenia. In: Cerebral Cortex. 2016 ; Vol. 26, No. 5. pp. 1891-1899.
@article{0fde9f737bc94f17bc2ecdd3223ce7ad,
title = "Electrophysiological Evidence for Impaired Control of Motor Output in Schizophrenia",
abstract = "Previous research has demonstrated pervasive deficits in response-related processing in people with schizophrenia (PSZ). The present study used behavioral measures and event-related potentials (ERPs) to test the hypothesis that schizophrenia involves specific impairment in the ability to exert control over response-related processing. Twenty-two PSZ and 22 matched control participants completed a choice response task in counterbalanced testing sessions that emphasized only accuracy (the unspeeded condition) or emphasized speed and accuracy equally (the speeded condition). Control participants successfully modulated behavioral and ERP indices of response-related processing under speed pressure, as evidenced by faster and less variable reaction times (RTs) and an earlier onset and increased amplitude lateralized readiness potential (LRP). By contrast, PSZ were unable to improve RT speed or variability or to modulate the LRP under speed pressure, despite showing a decrease in accuracy. Notably, response-related deficits in PSZ emerged only in the speeded condition; behavioral and ERP measures did not differ between groups in the unspeeded condition. Together, these results indicate that impairment in the ability to exert control over response-related processing may underlie response-related deficits in schizophrenia.",
keywords = "control, ERPs, lateralized readiness potential, motor, response preparation, schizophrenia",
author = "Kappenman, {Emily S.} and Luck, {Steven J.} and Kring, {Ann M.} and Lesh, {Tyler A.} and Mangun, {George R} and Niendam, {Tara A} and Ragland, {John D} and Charan Ranganath and Friedman, {Marjorie Solomon} and Swaab, {Tamara Y.} and Carter, {Cameron S}",
year = "2016",
month = "5",
day = "1",
doi = "10.1093/cercor/bhu329",
language = "English (US)",
volume = "26",
pages = "1891--1899",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Electrophysiological Evidence for Impaired Control of Motor Output in Schizophrenia

AU - Kappenman, Emily S.

AU - Luck, Steven J.

AU - Kring, Ann M.

AU - Lesh, Tyler A.

AU - Mangun, George R

AU - Niendam, Tara A

AU - Ragland, John D

AU - Ranganath, Charan

AU - Friedman, Marjorie Solomon

AU - Swaab, Tamara Y.

AU - Carter, Cameron S

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Previous research has demonstrated pervasive deficits in response-related processing in people with schizophrenia (PSZ). The present study used behavioral measures and event-related potentials (ERPs) to test the hypothesis that schizophrenia involves specific impairment in the ability to exert control over response-related processing. Twenty-two PSZ and 22 matched control participants completed a choice response task in counterbalanced testing sessions that emphasized only accuracy (the unspeeded condition) or emphasized speed and accuracy equally (the speeded condition). Control participants successfully modulated behavioral and ERP indices of response-related processing under speed pressure, as evidenced by faster and less variable reaction times (RTs) and an earlier onset and increased amplitude lateralized readiness potential (LRP). By contrast, PSZ were unable to improve RT speed or variability or to modulate the LRP under speed pressure, despite showing a decrease in accuracy. Notably, response-related deficits in PSZ emerged only in the speeded condition; behavioral and ERP measures did not differ between groups in the unspeeded condition. Together, these results indicate that impairment in the ability to exert control over response-related processing may underlie response-related deficits in schizophrenia.

AB - Previous research has demonstrated pervasive deficits in response-related processing in people with schizophrenia (PSZ). The present study used behavioral measures and event-related potentials (ERPs) to test the hypothesis that schizophrenia involves specific impairment in the ability to exert control over response-related processing. Twenty-two PSZ and 22 matched control participants completed a choice response task in counterbalanced testing sessions that emphasized only accuracy (the unspeeded condition) or emphasized speed and accuracy equally (the speeded condition). Control participants successfully modulated behavioral and ERP indices of response-related processing under speed pressure, as evidenced by faster and less variable reaction times (RTs) and an earlier onset and increased amplitude lateralized readiness potential (LRP). By contrast, PSZ were unable to improve RT speed or variability or to modulate the LRP under speed pressure, despite showing a decrease in accuracy. Notably, response-related deficits in PSZ emerged only in the speeded condition; behavioral and ERP measures did not differ between groups in the unspeeded condition. Together, these results indicate that impairment in the ability to exert control over response-related processing may underlie response-related deficits in schizophrenia.

KW - control

KW - ERPs

KW - lateralized readiness potential

KW - motor

KW - response preparation

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84965101872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965101872&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhu329

DO - 10.1093/cercor/bhu329

M3 - Article

C2 - 25618891

AN - SCOPUS:84965101872

VL - 26

SP - 1891

EP - 1899

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 5

ER -