Electrophysiological correlates of postural instability in Parkinson's disease

D. J. Beckley, B. R. Bloem, J. G. van Dijk, R. A C Roos, M. P. Remler

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Postural reflexes in response to sudden toe-up tilts of a supporting forceplate platform were studied in free-standing patients with stage III (N = 5) and stage IV (N = 5) Parkinson's disease and compared to 5 age- and sex-matched normals. Latencies of the short (SL), medium (ML) and long latency (LL) responses were normal in the patients. The normalized mean amplitudes of the ML responses were significantly increased only in the stage IV Parkinson patients (P < 0.0005). The distal-proximal activation sequence of LL responses observed in all 5 controls was reversed in 1 of the stage III and 4 of the stage IV Parkinson patients. Both the enlargement of the ML response (P < 0.01) and the inverted activation sequence of LL responses (P < 0.01) were significantly correlated with severity of the disease. The data establish an association between abnormal modulation of postural reflexes in the lower extremity and clinically rated balance in Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalElectroencephalography and Clinical Neurophysiology/ Evoked Potentials
Volume81
Issue number4
DOIs
StatePublished - 1991

Keywords

  • Activation sequence
  • EMG
  • Long latency reflex
  • Parkinson's disease
  • Postural control

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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