Electrophysiologic Confirmation of Heterogenous Motor Polyneuropathy in Young Cats

Monica R Aleman, Peter J Dickinson, D. C. Williams, Beverly Sturges, Richard A Lecouteur, Karen Vernau, G. D. Shelton

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Reports of motor polyneuropathies in young cats are scarce. Further, in-depth electrophysiologic evaluation to confirm a motor polyneuropathy in young cats of various breeds other than 2 Bengal cats is lacking. Hypothesis/Objectives: To confirm a motor polyneuropathy in young cats of various breeds. Animals: Five young cats with heterogenous chronic or relapsing episodes of weakness. Methods: Retrospective case series. Cats were presented for evaluation of generalized neuromuscular disease and underwent electrophysiologic examination including electromyography, nerve conduction, and repetitive nerve stimulation. Minimum database and muscle and nerve biopsy analyses were carried out. Descriptive statistics were performed. Results: Disease onset was at 3 months to 1 year of age and in 5 breeds. The most common clinical sign (5 of 5 cats) was weakness. Additional neurologic deficits consisted of palmigrade and plantigrade posture (4/4), low carriage of the head and tail (4/4), and variable segmental reflex deficits (5/5). Motor nerve conduction studies were abnormal for the ulnar (4/4), peroneal (5/5), and tibial (2/2) nerves (increased latencies, reduced amplitudes, slow velocities). A marked decrement was observed on repetitive nerve stimulation of the peroneal nerve in 3 cats for which autoimmune myasthenia gravis was ruled out. All sensory nerve conduction studies were normal. Histologic evaluation of muscle and nerve biopsies supported heterogenous alterations consistent with motor polyneuropathy with distal nerve fiber loss. Conclusions and Clinical Importance: Heterogenous motor polyneuropathies should be considered in young cats of any breed and sex that are presented with relapsing or progressive generalized neuromuscular disease.

Original languageEnglish (US)
Pages (from-to)1789-1798
Number of pages10
JournalJournal of Veterinary Internal Medicine
Volume28
Issue number6
DOIs
StatePublished - Nov 1 2014

Fingerprint

Polyneuropathies
nerve tissue
Cats
cats
Neural Conduction
neuromuscular disorders
Neuromuscular Diseases
biopsy
muscles
electromyography
Biopsy
Muscles
Peroneal Nerve
young animals
nerve fibers
motor neurons
posture
reflexes
Myasthenia Gravis
nervous system

Keywords

  • Feline
  • Nerve conduction
  • Neuromuscular
  • Weakness

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Electrophysiologic Confirmation of Heterogenous Motor Polyneuropathy in Young Cats. / Aleman, Monica R; Dickinson, Peter J; Williams, D. C.; Sturges, Beverly; Lecouteur, Richard A; Vernau, Karen; Shelton, G. D.

In: Journal of Veterinary Internal Medicine, Vol. 28, No. 6, 01.11.2014, p. 1789-1798.

Research output: Contribution to journalArticle

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