Electrophilic amination of organometallic reagents: Recent discoveries and mechanistic insights

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Abstract

Electrophilic amination constitutes a unique strategy for the synthesis of C-N bonds. One often-overlooked example of this type of process involves the reaction of organometallic nucleophiles with electrophilic nitrogen sources to yield aryl and alkyl amine derivatives. Such transformations are mechanistically intriguing and have the potential to drastically alter the logic by which nitrogencontaining compounds are synthesized.

Original languageEnglish (US)
Pages (from-to)341-346
Number of pages6
JournalMini-Reviews in Organic Chemistry
Volume8
Issue number3
DOIs
Publication statusPublished - Aug 1 2011
Externally publishedYes

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Keywords

  • Amination
  • C-N bonds
  • Electrophilic nitrogen
  • Mechanism
  • Organometallic reagents
  • Umpolung

ASJC Scopus subject areas

  • Organic Chemistry

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