Electrolyte effects on the activity of mutant enzymes in vivo and in vitro

Tadahiko Kohno; John Roth

Electrolyte effects on the activity of mutant enzymes in vivo and in vitro

Tadahiko Kohno, John Roth

Microbiology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

All temperature-sensitive histidine auxotrophs of Salmonella typhimurium tested are corrected by addition of neutral salts to their growth medium. The correctability seems to result from direct electrolyte effects on mutant protein stability since several of the mutant proteins are also salt correctable in vitro.

Original language	English (US)
Pages (from-to)	1386-1392
Number of pages	7
Journal	Biochemistry
Volume	18
Issue number	7
State	Published - 1979

ASJC Scopus subject areas

Biochemistry

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title = "Electrolyte effects on the activity of mutant enzymes in vivo and in vitro",

abstract = "All temperature-sensitive histidine auxotrophs of Salmonella typhimurium tested are corrected by addition of neutral salts to their growth medium. The correctability seems to result from direct electrolyte effects on mutant protein stability since several of the mutant proteins are also salt correctable in vitro.",

author = "Tadahiko Kohno and John Roth",

year = "1979",

language = "English (US)",

volume = "18",

pages = "1386--1392",

journal = "Biochemistry",

issn = "0006-2960",

publisher = "American Chemical Society",

number = "7",

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TY - JOUR

T1 - Electrolyte effects on the activity of mutant enzymes in vivo and in vitro

AU - Kohno, Tadahiko

AU - Roth, John

PY - 1979

Y1 - 1979

N2 - All temperature-sensitive histidine auxotrophs of Salmonella typhimurium tested are corrected by addition of neutral salts to their growth medium. The correctability seems to result from direct electrolyte effects on mutant protein stability since several of the mutant proteins are also salt correctable in vitro.

AB - All temperature-sensitive histidine auxotrophs of Salmonella typhimurium tested are corrected by addition of neutral salts to their growth medium. The correctability seems to result from direct electrolyte effects on mutant protein stability since several of the mutant proteins are also salt correctable in vitro.

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M3 - Article

C2 - 371678

AN - SCOPUS:0018780595

VL - 18

SP - 1386

EP - 1392

JO - Biochemistry

JF - Biochemistry

SN - 0006-2960

IS - 7

ER -

Electrolyte effects on the activity of mutant enzymes in vivo and in vitro

Abstract

ASJC Scopus subject areas

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