Electrolyte effects on the activity of mutant enzymes in vivo and in vitro

Tadahiko Kohno, John Roth

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

All temperature-sensitive histidine auxotrophs of Salmonella typhimurium tested are corrected by addition of neutral salts to their growth medium. The correctability seems to result from direct electrolyte effects on mutant protein stability since several of the mutant proteins are also salt correctable in vitro.

Original languageEnglish (US)
Pages (from-to)1386-1392
Number of pages7
JournalBiochemistry
Volume18
Issue number7
StatePublished - 1979

ASJC Scopus subject areas

  • Biochemistry

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