Abstract
Cortical EEG analysis of the effects of cholecystokinin (CCK) on sleep were performed in rats treated intraperitoneally with 1,10, or 20 ug/kg CCK8. Latency to the first episode of non-REM sleep was significantly reduced from 29 minutes to 16 minutes. No change in total waking time, total non-REM sleep, or total REM sleep was seen at any dose over the first hour after CCK administration. Locomotor activity was significantly reduced by 10 ug/kg CCK8 during the first ten minutes only. The temporal separation between the sleep-latency reduction and the behavioral inactivity induced by CCK indicate that these effects are distinguishable phenomena. Sleep does not appear to be a primary cause for the satiety-related behavioral effects of CCK.
Original language | English (US) |
---|---|
Pages (from-to) | 129-138 |
Number of pages | 10 |
Journal | Neuropeptides |
Volume | 3 |
Issue number | 2 |
DOIs | |
State | Published - 1982 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Clinical Neurology
- Neuroscience(all)
- Cellular and Molecular Neuroscience