Abstract
Cortical EEG analysis of the effects of cholecystokinin (CCK) on sleep were performed in rats treated intraperitoneally with 1,10, or 20 ug/kg CCK8. Latency to the first episode of non-REM sleep was significantly reduced from 29 minutes to 16 minutes. No change in total waking time, total non-REM sleep, or total REM sleep was seen at any dose over the first hour after CCK administration. Locomotor activity was significantly reduced by 10 ug/kg CCK8 during the first ten minutes only. The temporal separation between the sleep-latency reduction and the behavioral inactivity induced by CCK indicate that these effects are distinguishable phenomena. Sleep does not appear to be a primary cause for the satiety-related behavioral effects of CCK.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 129-138 |
| Number of pages | 10 |
| Journal | Neuropeptides |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Clinical Neurology
- Neuroscience(all)
- Cellular and Molecular Neuroscience
Cite this
Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin. / Rojas-Ramirez, Jose A.; Crawley, Jacqueline; Mendelson, Wallace B.
In: Neuropeptides, Vol. 3, No. 2, 1982, p. 129-138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin
AU - Rojas-Ramirez, Jose A.
AU - Crawley, Jacqueline
AU - Mendelson, Wallace B.
PY - 1982
Y1 - 1982
N2 - Cortical EEG analysis of the effects of cholecystokinin (CCK) on sleep were performed in rats treated intraperitoneally with 1,10, or 20 ug/kg CCK8. Latency to the first episode of non-REM sleep was significantly reduced from 29 minutes to 16 minutes. No change in total waking time, total non-REM sleep, or total REM sleep was seen at any dose over the first hour after CCK administration. Locomotor activity was significantly reduced by 10 ug/kg CCK8 during the first ten minutes only. The temporal separation between the sleep-latency reduction and the behavioral inactivity induced by CCK indicate that these effects are distinguishable phenomena. Sleep does not appear to be a primary cause for the satiety-related behavioral effects of CCK.
AB - Cortical EEG analysis of the effects of cholecystokinin (CCK) on sleep were performed in rats treated intraperitoneally with 1,10, or 20 ug/kg CCK8. Latency to the first episode of non-REM sleep was significantly reduced from 29 minutes to 16 minutes. No change in total waking time, total non-REM sleep, or total REM sleep was seen at any dose over the first hour after CCK administration. Locomotor activity was significantly reduced by 10 ug/kg CCK8 during the first ten minutes only. The temporal separation between the sleep-latency reduction and the behavioral inactivity induced by CCK indicate that these effects are distinguishable phenomena. Sleep does not appear to be a primary cause for the satiety-related behavioral effects of CCK.
UR - http://www.scopus.com/inward/record.url?scp=0020362917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020362917&partnerID=8YFLogxK
U2 - 10.1016/0143-4179(82)90008-7
DO - 10.1016/0143-4179(82)90008-7
M3 - Article
C2 - 7162563
AN - SCOPUS:0020362917
VL - 3
SP - 129
EP - 138
JO - Neuropeptides
JF - Neuropeptides
SN - 0143-4179
IS - 2
ER -