Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin

Jose A. Rojas-Ramirez; Jacqueline Crawley; Wallace B. Mendelson

doi:10.1016/0143-4179(82)90008-7

Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin

Jose A. Rojas-Ramirez, Jacqueline Crawley, Wallace B. Mendelson

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Cortical EEG analysis of the effects of cholecystokinin (CCK) on sleep were performed in rats treated intraperitoneally with 1,10, or 20 ug/kg CCK₈. Latency to the first episode of non-REM sleep was significantly reduced from 29 minutes to 16 minutes. No change in total waking time, total non-REM sleep, or total REM sleep was seen at any dose over the first hour after CCK administration. Locomotor activity was significantly reduced by 10 ug/kg CCK₈ during the first ten minutes only. The temporal separation between the sleep-latency reduction and the behavioral inactivity induced by CCK indicate that these effects are distinguishable phenomena. Sleep does not appear to be a primary cause for the satiety-related behavioral effects of CCK.

Original language	English (US)
Pages (from-to)	129-138
Number of pages	10
Journal	Neuropeptides
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/0143-4179(82)90008-7
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology
Endocrinology, Diabetes and Metabolism
Clinical Neurology
Neuroscience(all)
Cellular and Molecular Neuroscience

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10.1016/0143-4179(82)90008-7

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title = "Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin",

abstract = "Cortical EEG analysis of the effects of cholecystokinin (CCK) on sleep were performed in rats treated intraperitoneally with 1,10, or 20 ug/kg CCK8. Latency to the first episode of non-REM sleep was significantly reduced from 29 minutes to 16 minutes. No change in total waking time, total non-REM sleep, or total REM sleep was seen at any dose over the first hour after CCK administration. Locomotor activity was significantly reduced by 10 ug/kg CCK8 during the first ten minutes only. The temporal separation between the sleep-latency reduction and the behavioral inactivity induced by CCK indicate that these effects are distinguishable phenomena. Sleep does not appear to be a primary cause for the satiety-related behavioral effects of CCK.",

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AU - Rojas-Ramirez, Jose A.

AU - Crawley, Jacqueline

AU - Mendelson, Wallace B.

PY - 1982

Y1 - 1982

N2 - Cortical EEG analysis of the effects of cholecystokinin (CCK) on sleep were performed in rats treated intraperitoneally with 1,10, or 20 ug/kg CCK8. Latency to the first episode of non-REM sleep was significantly reduced from 29 minutes to 16 minutes. No change in total waking time, total non-REM sleep, or total REM sleep was seen at any dose over the first hour after CCK administration. Locomotor activity was significantly reduced by 10 ug/kg CCK8 during the first ten minutes only. The temporal separation between the sleep-latency reduction and the behavioral inactivity induced by CCK indicate that these effects are distinguishable phenomena. Sleep does not appear to be a primary cause for the satiety-related behavioral effects of CCK.

AB - Cortical EEG analysis of the effects of cholecystokinin (CCK) on sleep were performed in rats treated intraperitoneally with 1,10, or 20 ug/kg CCK8. Latency to the first episode of non-REM sleep was significantly reduced from 29 minutes to 16 minutes. No change in total waking time, total non-REM sleep, or total REM sleep was seen at any dose over the first hour after CCK administration. Locomotor activity was significantly reduced by 10 ug/kg CCK8 during the first ten minutes only. The temporal separation between the sleep-latency reduction and the behavioral inactivity induced by CCK indicate that these effects are distinguishable phenomena. Sleep does not appear to be a primary cause for the satiety-related behavioral effects of CCK.

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Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin

Abstract

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