Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin

Jose A. Rojas-Ramirez, Jacqueline Crawley, Wallace B. Mendelson

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Cortical EEG analysis of the effects of cholecystokinin (CCK) on sleep were performed in rats treated intraperitoneally with 1,10, or 20 ug/kg CCK8. Latency to the first episode of non-REM sleep was significantly reduced from 29 minutes to 16 minutes. No change in total waking time, total non-REM sleep, or total REM sleep was seen at any dose over the first hour after CCK administration. Locomotor activity was significantly reduced by 10 ug/kg CCK8 during the first ten minutes only. The temporal separation between the sleep-latency reduction and the behavioral inactivity induced by CCK indicate that these effects are distinguishable phenomena. Sleep does not appear to be a primary cause for the satiety-related behavioral effects of CCK.

Original languageEnglish (US)
Pages (from-to)129-138
Number of pages10
Issue number2
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience


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