Electrically induced hippocampal and cortical seizures and their effects on operant behavior

Timothy E Albertson; L. G. Stark; C. McCormack

Electrically induced hippocampal and cortical seizures and their effects on operant behavior

Timothy E Albertson, L. G. Stark, C. McCormack

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Food deprived, free moving rats bearing chronically implanted electrodes were operantly trained. The effects of hippocampal and cortical electrically induced seizures while the animals were bar pressing were studied. There was no significant difference in latency to regain behavior between the 2 experimental groups nor in time to regain stable EEG. Cortical seizures, however, lasted significantly longer (p<.025) and were more severe (p<.05). This model offers new measures for the behavioral quantification of preseizure and postseizure effectiveness of anticonvulsant drugs.

Original language	English (US)
Pages (from-to)	17
Number of pages	1
Journal	Pharmacologist
Volume	17
Issue number	2
State	Published - 1975

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)

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abstract = "Food deprived, free moving rats bearing chronically implanted electrodes were operantly trained. The effects of hippocampal and cortical electrically induced seizures while the animals were bar pressing were studied. There was no significant difference in latency to regain behavior between the 2 experimental groups nor in time to regain stable EEG. Cortical seizures, however, lasted significantly longer (p<.025) and were more severe (p<.05). This model offers new measures for the behavioral quantification of preseizure and postseizure effectiveness of anticonvulsant drugs.",

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