Abstract
Food deprived, free moving rats bearing chronically implanted electrodes were operantly trained. The effects of hippocampal and cortical electrically induced seizures while the animals were bar pressing were studied. There was no significant difference in latency to regain behavior between the 2 experimental groups nor in time to regain stable EEG. Cortical seizures, however, lasted significantly longer (p<.025) and were more severe (p<.05). This model offers new measures for the behavioral quantification of preseizure and postseizure effectiveness of anticonvulsant drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 17 |
| Number of pages | 1 |
| Journal | Pharmacologist |
| Volume | 17 |
| Issue number | 2 |
| State | Published - 1975 |
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ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Electrically induced hippocampal and cortical seizures and their effects on operant behavior. / Albertson, Timothy E; Stark, L. G.; McCormack, C.
In: Pharmacologist, Vol. 17, No. 2, 1975, p. 17.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electrically induced hippocampal and cortical seizures and their effects on operant behavior
AU - Albertson, Timothy E
AU - Stark, L. G.
AU - McCormack, C.
PY - 1975
Y1 - 1975
N2 - Food deprived, free moving rats bearing chronically implanted electrodes were operantly trained. The effects of hippocampal and cortical electrically induced seizures while the animals were bar pressing were studied. There was no significant difference in latency to regain behavior between the 2 experimental groups nor in time to regain stable EEG. Cortical seizures, however, lasted significantly longer (p<.025) and were more severe (p<.05). This model offers new measures for the behavioral quantification of preseizure and postseizure effectiveness of anticonvulsant drugs.
AB - Food deprived, free moving rats bearing chronically implanted electrodes were operantly trained. The effects of hippocampal and cortical electrically induced seizures while the animals were bar pressing were studied. There was no significant difference in latency to regain behavior between the 2 experimental groups nor in time to regain stable EEG. Cortical seizures, however, lasted significantly longer (p<.025) and were more severe (p<.05). This model offers new measures for the behavioral quantification of preseizure and postseizure effectiveness of anticonvulsant drugs.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016822685&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0016822685
VL - 17
SP - 17
JO - Pharmacologist
JF - Pharmacologist
SN - 0031-7004
IS - 2
ER -