Electrically guiding nerve growth and neuronal migration

Lei Zhang, Zhengping Yu, Min Zhao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Guided and stimulated nerve growth and neuronal migration is critical to repairing diseased or damaged nervous systems. Electric fields (EFs) provide a powerful signal to stimulate and guide nerve growth and neuronal migration. EFs may direct axon outgrowth, orientate cell polarity, and guide neuronal migration. These effects may be mediated through activation of important intracellular signaling pathways and orientation of important organelles. The potential use of EFs in the nervous system may provide new therapies for neurodevelopmental disorders and brain injuries. This chapter aims to review recent experimental data on EFs-guided nerve growth and neuronal migration, and possible molecular and cellular mechanisms.

Original languageEnglish (US)
Title of host publicationNeuronal Migration: Disorders, Genetic Factors and Treatment Options
PublisherNova Science Publishers, Inc.
Pages51-76
Number of pages26
ISBN (Print)9781621000594
StatePublished - Aug 2012

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ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Zhang, L., Yu, Z., & Zhao, M. (2012). Electrically guiding nerve growth and neuronal migration. In Neuronal Migration: Disorders, Genetic Factors and Treatment Options (pp. 51-76). Nova Science Publishers, Inc..