Guided and stimulated nerve growth and neuronal migration is critical to repairing diseased or damaged nervous systems. Electric fields (EFs) provide a powerful signal to stimulate and guide nerve growth and neuronal migration. EFs may direct axon outgrowth, orientate cell polarity, and guide neuronal migration. These effects may be mediated through activation of important intracellular signaling pathways and orientation of important organelles. The potential use of EFs in the nervous system may provide new therapies for neurodevelopmental disorders and brain injuries. This chapter aims to review recent experimental data on EFs-guided nerve growth and neuronal migration, and possible molecular and cellular mechanisms.
|Original language||English (US)|
|Title of host publication||Neuronal Migration: Disorders, Genetic Factors and Treatment Options|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||26|
|State||Published - Aug 2012|
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