Electrical signaling in control of ocular cell behaviors

Min Zhao, Laura Chalmers, Lin Cao, Ana C. Vieira, Mark J Mannis, Brian Reid

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Epithelia of the cornea, lens and retina contain a vast array of ion channels and pumps. Together they produce a polarized flow of ions in and out of cells, as well as across the epithelia. These naturally occurring ion fluxes are essential to the hydration and metabolism of the ocular tissues, especially for the avascular cornea and lens. The directional transport of ions generates electric fields and currents in those tissues. Applied electric fields affect migration, division and proliferation of ocular cells which are important in homeostasis and healing of the ocular tissues. Abnormalities in any of those aspects may underlie many ocular diseases, for example chronic corneal ulcers, posterior capsule opacity after cataract surgery, and retinopathies. Electric field-inducing cellular responses, termed electrical signaling here, therefore may be an unexpected yet powerful mechanism in regulating ocular cell behavior. Both endogenous electric fields and applied electric fields could be exploited to regulate ocular cells. We aim to briefly describe the physiology of the naturally occurring electrical activities in the corneal, lens, and retinal epithelia, to provide experimental evidence of the effects of electric fields on ocular cell behaviors, and to suggest possible clinical implications.

Original languageEnglish (US)
Pages (from-to)65-88
Number of pages24
JournalProgress in Retinal and Eye Research
Volume31
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Lenses
Epithelium
Cornea
Ion Pumps
Ions
Corneal Ulcer
Eye Diseases
Ion Transport
Ion Channels
Cataract
Capsules
Retina
Homeostasis
Cell Proliferation

Keywords

  • Cell migration
  • Cell proliferation
  • Electric field
  • Electrotaxis/galvanotaxis
  • Ion flux
  • Wound healing

ASJC Scopus subject areas

  • Sensory Systems
  • Ophthalmology

Cite this

Electrical signaling in control of ocular cell behaviors. / Zhao, Min; Chalmers, Laura; Cao, Lin; Vieira, Ana C.; Mannis, Mark J; Reid, Brian.

In: Progress in Retinal and Eye Research, Vol. 31, No. 1, 01.2012, p. 65-88.

Research output: Contribution to journalArticle

Zhao, Min ; Chalmers, Laura ; Cao, Lin ; Vieira, Ana C. ; Mannis, Mark J ; Reid, Brian. / Electrical signaling in control of ocular cell behaviors. In: Progress in Retinal and Eye Research. 2012 ; Vol. 31, No. 1. pp. 65-88.
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