Electrical activity as a developmental regulator in the formation of spinal cord circuits

Laura N Borodinsky, Yesser Hadj Belgacem, Immani Swapna

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Spinal cord development is a complex process involving generation of the appropriate number of cells, acquisition of distinctive phenotypes and establishment of functional connections that enable execution of critical functions such as sensation and locomotion. Here we review the basic cellular events occurring during spinal cord development, highlighting studies that demonstrate the roles of electrical activity in this process. We conclude that the participation of different forms of electrical activity is evident from the beginning of spinal cord development and intermingles with other developmental cues and programs to implement dynamic and integrated control of spinal cord function.

Original languageEnglish (US)
Pages (from-to)624-630
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume22
Issue number4
DOIs
StatePublished - Aug 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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