TY - JOUR
T1 - Electrical activity as a developmental regulator in the formation of spinal cord circuits
AU - Borodinsky, Laura N
AU - Belgacem, Yesser Hadj
AU - Swapna, Immani
PY - 2012/8
Y1 - 2012/8
N2 - Spinal cord development is a complex process involving generation of the appropriate number of cells, acquisition of distinctive phenotypes and establishment of functional connections that enable execution of critical functions such as sensation and locomotion. Here we review the basic cellular events occurring during spinal cord development, highlighting studies that demonstrate the roles of electrical activity in this process. We conclude that the participation of different forms of electrical activity is evident from the beginning of spinal cord development and intermingles with other developmental cues and programs to implement dynamic and integrated control of spinal cord function.
AB - Spinal cord development is a complex process involving generation of the appropriate number of cells, acquisition of distinctive phenotypes and establishment of functional connections that enable execution of critical functions such as sensation and locomotion. Here we review the basic cellular events occurring during spinal cord development, highlighting studies that demonstrate the roles of electrical activity in this process. We conclude that the participation of different forms of electrical activity is evident from the beginning of spinal cord development and intermingles with other developmental cues and programs to implement dynamic and integrated control of spinal cord function.
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U2 - 10.1016/j.conb.2012.02.004
DO - 10.1016/j.conb.2012.02.004
M3 - Article
C2 - 22370142
AN - SCOPUS:84865964551
VL - 22
SP - 624
EP - 630
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 4
ER -