Elastin turnover in murine lung after repeated ozone exposure

Michael A. Dubick, Robert B. Rucker, Jerold A Last, Lance O. Lollini, Carroll E Cross

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Several lines of evidence suggest that ozone (O3) may affect the connective tissue elements of the lung. Since alterations in the elastic properties of lung parenchyma have been implicated in two major forms of lung pathology, fibrosis and emphysema, lung elastin turnover was examined in mice repeatedly exposed to O3. Swiss-Webster (ice were injected with l-[14C]lysine to radiochemically label the cross-linking amino acids (desmosines) of elastin. Three weeks later, they were exposed to either 1.5 ppm O3 or filtered air for 4 days. Mice were then exposed every 8 weeks for a total of three exposures. Although a physical separation of the elastic fibers was noted in the more edematous areas of the O3 exposed lung, lung elastin turnover, as measured by the change in radioactivity of the desmosines, was not significantly altered.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalToxicology and Applied Pharmacology
Volume58
Issue number2
DOIs
StatePublished - 1981

Fingerprint

Elastin
Ozone
Desmosine
Lung
Radioactivity
Ice
Pathology
Lysine
Labels
Tissue
Amino Acids
Elastic Tissue
Fibers
Emphysema
Air
Connective Tissue
Fibrosis

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Elastin turnover in murine lung after repeated ozone exposure. / Dubick, Michael A.; Rucker, Robert B.; Last, Jerold A; Lollini, Lance O.; Cross, Carroll E.

In: Toxicology and Applied Pharmacology, Vol. 58, No. 2, 1981, p. 203-210.

Research output: Contribution to journalArticle

Dubick, Michael A. ; Rucker, Robert B. ; Last, Jerold A ; Lollini, Lance O. ; Cross, Carroll E. / Elastin turnover in murine lung after repeated ozone exposure. In: Toxicology and Applied Pharmacology. 1981 ; Vol. 58, No. 2. pp. 203-210.
@article{e7153672111c4cd393d0690da5592d84,
title = "Elastin turnover in murine lung after repeated ozone exposure",
abstract = "Several lines of evidence suggest that ozone (O3) may affect the connective tissue elements of the lung. Since alterations in the elastic properties of lung parenchyma have been implicated in two major forms of lung pathology, fibrosis and emphysema, lung elastin turnover was examined in mice repeatedly exposed to O3. Swiss-Webster (ice were injected with l-[14C]lysine to radiochemically label the cross-linking amino acids (desmosines) of elastin. Three weeks later, they were exposed to either 1.5 ppm O3 or filtered air for 4 days. Mice were then exposed every 8 weeks for a total of three exposures. Although a physical separation of the elastic fibers was noted in the more edematous areas of the O3 exposed lung, lung elastin turnover, as measured by the change in radioactivity of the desmosines, was not significantly altered.",
author = "Dubick, {Michael A.} and Rucker, {Robert B.} and Last, {Jerold A} and Lollini, {Lance O.} and Cross, {Carroll E}",
year = "1981",
doi = "10.1016/0041-008X(81)90424-5",
language = "English (US)",
volume = "58",
pages = "203--210",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Elastin turnover in murine lung after repeated ozone exposure

AU - Dubick, Michael A.

AU - Rucker, Robert B.

AU - Last, Jerold A

AU - Lollini, Lance O.

AU - Cross, Carroll E

PY - 1981

Y1 - 1981

N2 - Several lines of evidence suggest that ozone (O3) may affect the connective tissue elements of the lung. Since alterations in the elastic properties of lung parenchyma have been implicated in two major forms of lung pathology, fibrosis and emphysema, lung elastin turnover was examined in mice repeatedly exposed to O3. Swiss-Webster (ice were injected with l-[14C]lysine to radiochemically label the cross-linking amino acids (desmosines) of elastin. Three weeks later, they were exposed to either 1.5 ppm O3 or filtered air for 4 days. Mice were then exposed every 8 weeks for a total of three exposures. Although a physical separation of the elastic fibers was noted in the more edematous areas of the O3 exposed lung, lung elastin turnover, as measured by the change in radioactivity of the desmosines, was not significantly altered.

AB - Several lines of evidence suggest that ozone (O3) may affect the connective tissue elements of the lung. Since alterations in the elastic properties of lung parenchyma have been implicated in two major forms of lung pathology, fibrosis and emphysema, lung elastin turnover was examined in mice repeatedly exposed to O3. Swiss-Webster (ice were injected with l-[14C]lysine to radiochemically label the cross-linking amino acids (desmosines) of elastin. Three weeks later, they were exposed to either 1.5 ppm O3 or filtered air for 4 days. Mice were then exposed every 8 weeks for a total of three exposures. Although a physical separation of the elastic fibers was noted in the more edematous areas of the O3 exposed lung, lung elastin turnover, as measured by the change in radioactivity of the desmosines, was not significantly altered.

UR - http://www.scopus.com/inward/record.url?scp=0019495797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019495797&partnerID=8YFLogxK

U2 - 10.1016/0041-008X(81)90424-5

DO - 10.1016/0041-008X(81)90424-5

M3 - Article

VL - 58

SP - 203

EP - 210

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 2

ER -