Abstract
Several lines of evidence suggest that ozone (O3) may affect the connective tissue elements of the lung. Since alterations in the elastic properties of lung parenchyma have been implicated in two major forms of lung pathology, fibrosis and emphysema, lung elastin turnover was examined in mice repeatedly exposed to O3. Swiss-Webster (ice were injected with l-[14C]lysine to radiochemically label the cross-linking amino acids (desmosines) of elastin. Three weeks later, they were exposed to either 1.5 ppm O3 or filtered air for 4 days. Mice were then exposed every 8 weeks for a total of three exposures. Although a physical separation of the elastic fibers was noted in the more edematous areas of the O3 exposed lung, lung elastin turnover, as measured by the change in radioactivity of the desmosines, was not significantly altered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 203-210 |
| Number of pages | 8 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 58 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Elastin turnover in murine lung after repeated ozone exposure. / Dubick, Michael A.; Rucker, Robert B.; Last, Jerold A; Lollini, Lance O.; Cross, Carroll E.
In: Toxicology and Applied Pharmacology, Vol. 58, No. 2, 1981, p. 203-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elastin turnover in murine lung after repeated ozone exposure
AU - Dubick, Michael A.
AU - Rucker, Robert B.
AU - Last, Jerold A
AU - Lollini, Lance O.
AU - Cross, Carroll E
PY - 1981
Y1 - 1981
N2 - Several lines of evidence suggest that ozone (O3) may affect the connective tissue elements of the lung. Since alterations in the elastic properties of lung parenchyma have been implicated in two major forms of lung pathology, fibrosis and emphysema, lung elastin turnover was examined in mice repeatedly exposed to O3. Swiss-Webster (ice were injected with l-[14C]lysine to radiochemically label the cross-linking amino acids (desmosines) of elastin. Three weeks later, they were exposed to either 1.5 ppm O3 or filtered air for 4 days. Mice were then exposed every 8 weeks for a total of three exposures. Although a physical separation of the elastic fibers was noted in the more edematous areas of the O3 exposed lung, lung elastin turnover, as measured by the change in radioactivity of the desmosines, was not significantly altered.
AB - Several lines of evidence suggest that ozone (O3) may affect the connective tissue elements of the lung. Since alterations in the elastic properties of lung parenchyma have been implicated in two major forms of lung pathology, fibrosis and emphysema, lung elastin turnover was examined in mice repeatedly exposed to O3. Swiss-Webster (ice were injected with l-[14C]lysine to radiochemically label the cross-linking amino acids (desmosines) of elastin. Three weeks later, they were exposed to either 1.5 ppm O3 or filtered air for 4 days. Mice were then exposed every 8 weeks for a total of three exposures. Although a physical separation of the elastic fibers was noted in the more edematous areas of the O3 exposed lung, lung elastin turnover, as measured by the change in radioactivity of the desmosines, was not significantly altered.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019495797&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(81)90424-5
DO - 10.1016/0041-008X(81)90424-5
M3 - Article
VL - 58
SP - 203
EP - 210
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 2
ER -