Elastin metabolism in rodent lung

Michael A. Dubick, Robert B. Rucker, Carroll E Cross, Jerold A Last

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Data from the in vivo incorporation of [3H]valine into fractions of elastin obtained from rat or mouse lung suggest that postnatal lung elastin synthesis occurs predominantly in the first 1 to 2 weeks of life. Very little [3H]valine was incorporated into lung elastin obtained from adult animals. When lung elastin from neonatal mice was radiochemically labelled with [14C]lysine as a single pulse, it was observed that the specific activity of the elastin expressed as the total dpm values as 14C per mg was not significantly altered over a 6 month period. Elastin appears to turn over very slowly in mouse lung with half-life best estimated in years.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalBBA - General Subjects
Volume672
Issue number3
DOIs
StatePublished - Feb 5 1981

Fingerprint

Elastin
Metabolism
Rodentia
Lung
Valine
Lysine
Half-Life
Rats
Animals

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Medicine(all)

Cite this

Elastin metabolism in rodent lung. / Dubick, Michael A.; Rucker, Robert B.; Cross, Carroll E; Last, Jerold A.

In: BBA - General Subjects, Vol. 672, No. 3, 05.02.1981, p. 303-306.

Research output: Contribution to journalArticle

Dubick, Michael A. ; Rucker, Robert B. ; Cross, Carroll E ; Last, Jerold A. / Elastin metabolism in rodent lung. In: BBA - General Subjects. 1981 ; Vol. 672, No. 3. pp. 303-306.
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