Elastin metabolism in rodent lung

Michael A. Dubick, Robert B. Rucker, Carroll E Cross, Jerold A Last

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Data from the in vivo incorporation of [3H]valine into fractions of elastin obtained from rat or mouse lung suggest that postnatal lung elastin synthesis occurs predominantly in the first 1 to 2 weeks of life. Very little [3H]valine was incorporated into lung elastin obtained from adult animals. When lung elastin from neonatal mice was radiochemically labelled with [14C]lysine as a single pulse, it was observed that the specific activity of the elastin expressed as the total dpm values as 14C per mg was not significantly altered over a 6 month period. Elastin appears to turn over very slowly in mouse lung with half-life best estimated in years.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalBBA - General Subjects
Volume672
Issue number3
DOIs
StatePublished - Feb 5 1981

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Medicine(all)

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