Abstract
A prototype small animal positron emission tomography (PET) scanner for mouse brain imaging has been developed at UC Davis. The new scanner uses tapered detector arrays with depth of interaction (DOI) measurement. In this paper, we present an efficient system model for the tapered PET scanner using matrix factorization and a virtual scanner geometry. The factored system matrix mainly consists of two components: a sinogram blurring matrix and a geometrical matrix. The geometric matrix is based on a virtual scanner geometry. The sinogram blurring matrix is estimated by matrix factorization. We investigate the performance of different virtual scanner geometries. Both simulation study and real data experiments are performed in the fully 3D mode to study the image quality under different system models. The results indicate that the proposed matrix factorization can maintain image quality while substantially reduce the image reconstruction time and system matrix storage cost. The proposed method can be also applied to other PET scanners with DOI measurement.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 461-474 |
| Number of pages | 14 |
| Journal | Physics in Medicine and Biology |
| Volume | 61 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 18 2015 |
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Keywords
- image reconstruction
- positron emission tomography
- system modeling
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Efficient system modeling for a small animal PET scanner with tapered DOI detectors. / Zhang, Mengxi; Zhou, Jian; Yang, Yongfeng; Rodríguez-Villafuerte, Mercedes; Qi, Jinyi.
In: Physics in Medicine and Biology, Vol. 61, No. 2, 18.12.2015, p. 461-474.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficient system modeling for a small animal PET scanner with tapered DOI detectors
AU - Zhang, Mengxi
AU - Zhou, Jian
AU - Yang, Yongfeng
AU - Rodríguez-Villafuerte, Mercedes
AU - Qi, Jinyi
PY - 2015/12/18
Y1 - 2015/12/18
N2 - A prototype small animal positron emission tomography (PET) scanner for mouse brain imaging has been developed at UC Davis. The new scanner uses tapered detector arrays with depth of interaction (DOI) measurement. In this paper, we present an efficient system model for the tapered PET scanner using matrix factorization and a virtual scanner geometry. The factored system matrix mainly consists of two components: a sinogram blurring matrix and a geometrical matrix. The geometric matrix is based on a virtual scanner geometry. The sinogram blurring matrix is estimated by matrix factorization. We investigate the performance of different virtual scanner geometries. Both simulation study and real data experiments are performed in the fully 3D mode to study the image quality under different system models. The results indicate that the proposed matrix factorization can maintain image quality while substantially reduce the image reconstruction time and system matrix storage cost. The proposed method can be also applied to other PET scanners with DOI measurement.
AB - A prototype small animal positron emission tomography (PET) scanner for mouse brain imaging has been developed at UC Davis. The new scanner uses tapered detector arrays with depth of interaction (DOI) measurement. In this paper, we present an efficient system model for the tapered PET scanner using matrix factorization and a virtual scanner geometry. The factored system matrix mainly consists of two components: a sinogram blurring matrix and a geometrical matrix. The geometric matrix is based on a virtual scanner geometry. The sinogram blurring matrix is estimated by matrix factorization. We investigate the performance of different virtual scanner geometries. Both simulation study and real data experiments are performed in the fully 3D mode to study the image quality under different system models. The results indicate that the proposed matrix factorization can maintain image quality while substantially reduce the image reconstruction time and system matrix storage cost. The proposed method can be also applied to other PET scanners with DOI measurement.
KW - image reconstruction
KW - positron emission tomography
KW - system modeling
UR - http://www.scopus.com/inward/record.url?scp=84955492401&partnerID=8YFLogxK
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U2 - 10.1088/0031-9155/61/2/461
DO - 10.1088/0031-9155/61/2/461
M3 - Article
VL - 61
SP - 461
EP - 474
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
SN - 0031-9155
IS - 2
ER -